Brown M R, Cohen H J, Lyons J M, Curtis T W, Thunberg B, Cochran W J, Klish W J
Am J Clin Nutr. 1986 Apr;43(4):549-54. doi: 10.1093/ajcn/43.4.549.
A 33-yr-old white female with short bowel syndrome secondary to trauma was maintained on home parenteral nutrition for 4 yr when her plasma, red cell, white cell, and platelet glutathione peroxidase (GSHPx) activities were found to be extremely low, as were her plasma and red cell selenium levels. During her first year on parenteral nutrition she noted the onset of an inability to rise from a squatting position, rapid tiring when stair climbing, and weakness when attempting to lift large or moderately heavy objects. Treatment with 400 micrograms/d of selenious acid intravenously was associated with a disappearance of her symptoms and an increase in proximal muscle strength within 6 wk. The plasma and red cell selenium levels, and the plasma and white cell GSHPx activities rose to normal levels within 6 wk. Red cell GSHPx activity returned to normal by 3 mo.
一名33岁的白人女性因创伤继发短肠综合征，接受家庭肠外营养4年，此时发现她的血浆、红细胞、白细胞和血小板谷胱甘肽过氧化物酶（GSHPx）活性极低，血浆和红细胞硒水平也很低。在接受肠外营养的第一年，她注意到自己开始无法从蹲姿站起，爬楼梯时很快就感到疲倦，试图举起大型或中等重量的物体时感到无力。静脉注射400微克/天的亚硒酸治疗6周内，她的症状消失，近端肌肉力量增强。血浆和红细胞硒水平以及血浆和白细胞GSHPx活性在6周内升至正常水平。红细胞GSHPx活性在3个月时恢复正常。
