Olsen Renate Slind, Dimberg Jan, Geffers Robert, Wågsäter Dick
a Department of Laboratory Medicine, Division of Medical Diagnostics , Region Jönköping County , Jönköping , Sweden.
b Division of Drug Research, Department of Medicine and Health Sciences, Faculty of Medicine and Health Sciences , Linköping University , Linköping , Sweden.
Cancer Invest. 2019;37(2):99-112. doi: 10.1080/07357907.2019.1576191. Epub 2019 Mar 5.
Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal tissues. PDGF-D stimulation of cells altered genes of importance in carcinogenic processes. In addition, PDGF-D increased the proliferation rate while imatinib inhibited these effects. PDGF-D and its PDGF receptor beta (PDGFR-β) are expressed in colorectal cancer and blockage of PDGF-D/PDGFR-β signaling using tyrosine kinase inhibitors, such as imatinib, might be important in inhibiting tumor-promoting actions.
血小板衍生生长因子D（PDGF-D）已被证明可介导癌症进展中重要的细胞过程。本研究旨在调查PDGF-D信号在结直肠癌发生中的表达及可能的作用。PDGF-D在肿瘤组织和正常组织的血管内皮细胞中均有表达。PDGF-D刺激细胞会改变致癌过程中的重要基因。此外，PDGF-D可提高增殖率，而伊马替尼可抑制这些作用。PDGF-D及其血小板衍生生长因子受体β（PDGFR-β）在结直肠癌中均有表达，使用酪氨酸激酶抑制剂（如伊马替尼）阻断PDGF-D/PDGFR-β信号可能对抑制肿瘤促进作用具有重要意义。
