Zhao Xia, Yu Zhihao, Zang Ku
Department of Ultrasound Medicine, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian 223300, China.
Department of Intensive Care Unit, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian 223300, China.
J Oncol. 2022 Aug 18;2022:2108368. doi: 10.1155/2022/2108368. eCollection 2022.
To investigate the association of platelet-derived growth factors (PDGFs), clinicopathological features, and prognosis in gastric cancer patients.
Tumor specimens of 180 individuals with gastric cancer treated between 2016 and 2020 were collected. Immunohistochemical staining and Western blot (WB) were used to detect the expression of PDGF-B and PDGF-D. The relationship between the expression of PDGF-B and PDGF-D and relapse-free subsistence (RFS) time was assessed using Kaplan-Meier curves. Univariate and multivariate Cox proportional hazards regression models were used to evaluate the relationship between the expression of PDGF-B and PDGF-D and the prognosis and clinicopathological features in gastric cancer patients.
High expression of PDGF-B and PDGF-D was detected in 108 (60%) and 137 (76%) tumor specimens, respectively. The expressions of PDGF-B and PDGF-D were independent predictive indicators in multivariate analysis when compared to tumor depth, tumor stage, lymph node metastasis, and RFS ( < 0.01).
The high expression of PDGF-B and PDGF-D in gastric cancer tissues is associated with poor prognosis and poor survival rate of the patients. The expression of PDGF-B and PDGF-D can be used as important indicators to evaluate the biological behavior and prognosis of gastric cancer.
探讨血小板衍生生长因子（PDGFs）与胃癌患者临床病理特征及预后的相关性。
收集2016年至2020年间接受治疗的180例胃癌患者的肿瘤标本。采用免疫组织化学染色和蛋白质印迹法（WB）检测PDGF - B和PDGF - D的表达。使用Kaplan - Meier曲线评估PDGF - B和PDGF - D的表达与无复发生存（RFS）时间之间的关系。采用单因素和多因素Cox比例风险回归模型评估PDGF - B和PDGF - D的表达与胃癌患者预后及临床病理特征之间的关系。
分别在108例（60%）和137例（76%）肿瘤标本中检测到PDGF - B和PDGF - D的高表达。与肿瘤深度、肿瘤分期、淋巴结转移和RFS相比，在多因素分析中，PDGF - B和PDGF - D的表达是独立的预测指标（<0.01）。
胃癌组织中PDGF - B和PDGF - D的高表达与患者预后不良及生存率低相关。PDGF - B和PDGF - D的表达可作为评估胃癌生物学行为和预后的重要指标。
