Grote J J, van Blitterswijk C A, Kuijpers W
Ann Otol Rhinol Laryngol Suppl. 1986 Mar-Apr;123:1-5. doi: 10.1177/00034894860950s201.
Hydroxyapatite is the main constituent of the mineral matrix of bone. The behavior of porous and dense hydroxyapatite ceramic implants was studied in normal rat middle ears, after induced infection, and in an in vitro assay by light and electron microscopic techniques. All implants were integrated into the middle ears without signs of extrusion, and their mucosal coverings did not appear to differ fundamentally from those of normal ears. The porous hydroxyapatite became filled with fibrous tissue and bone that showed normal morphology, and there was direct bonding of the bone to the implants. Minor biodegradation was established for the porous implants. Hydroxyapatite did not affect cultured middle ear mucosa significantly in vitro. Induced infection failed to show any adverse effect on the behavior of the implants. These observations suggest that hydroxyapatite is very useful for reconstructive ear surgery.
羟基磷灰石是骨矿物质基质的主要成分。采用光镜和电镜技术，对正常大鼠中耳、诱导感染后的大鼠中耳以及体外实验中多孔和致密羟基磷灰石陶瓷植入物的行为进行了研究。所有植入物均整合到中耳中，无挤出迹象，其黏膜覆盖物与正常耳的黏膜覆盖物在本质上似乎没有差异。多孔羟基磷灰石被纤维组织和形态正常的骨填充，骨与植入物直接结合。已确定多孔植入物有轻微的生物降解。羟基磷灰石在体外对培养的中耳黏膜影响不显著。诱导感染未对植入物的行为产生任何不良影响。这些观察结果表明，羟基磷灰石对耳再造手术非常有用。
