van Blitterswijk C A, Grote J J, Kuÿpers W, Blok-van Hoek C J, Daems W T
Biomaterials. 1985 Jul;6(4):243-51. doi: 10.1016/0142-9612(85)90020-1.
The events at the hydroxyapatite implant material/tissue interface in the rat middle ear were studied by light microscopy, autoradiography, morphometry, transmission electron microscopy (TEM), scanning electron microscopy (SEM), and X-ray microanalysis. Deposition of calcium, partially in the form of calcium phosphate, was found at the interface. Resorption of the implant material occurred as the result of mono- and multinuclear phagocyte activity. Resorption decreased 6 mnth after the operation, possibly due to the decreasing number of phagocytes at the interface and the increasing amount of bone in the macropores.
通过光学显微镜、放射自显影、形态计量学、透射电子显微镜（TEM）、扫描电子显微镜（SEM）和X射线微分析，研究了大鼠中耳羟基磷灰石植入材料/组织界面处的情况。在界面处发现了钙的沉积，部分呈磷酸钙形式。植入材料的吸收是单核和多核吞噬细胞活动的结果。术后6个月吸收减少，可能是由于界面处吞噬细胞数量减少以及大孔中骨量增加所致。
