Williams Dominique E, Grant Kathryn B
Department of Chemistry, University of Richmond, Richmond, VA, United States.
Department of Chemistry, Georgia State University, Atlanta, GA, United States.
Front Chem. 2019 Feb 19;7:14. doi: 10.3389/fchem.2019.00014. eCollection 2019.
This report covers major advances in the use of metal ions and complexes to hydrolyze ester and phosphate ester lipid bonds. These metal-based Lewis acids have been investigated as catalysts to isolate fatty acids from biological sources, as probes to study phospholipid bilayer properties, as tools to examine signal transduction pathways, and as lead compounds toward the discovery of therapeutic agents. Metal ions that accelerate phosphate ester hydrolysis under mild conditions of temperature and pH may have the potential to mimic phospholipase activity in biochemical applications.
本报告涵盖了使用金属离子和配合物水解酯键和磷酸酯脂质键方面的主要进展。这些基于金属的路易斯酸已被作为从生物源中分离脂肪酸的催化剂、研究磷脂双层性质的探针、检测信号转导途径的工具以及用于发现治疗剂的先导化合物进行了研究。在温和的温度和pH条件下加速磷酸酯水解的金属离子在生化应用中可能具有模拟磷脂酶活性的潜力。
