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从肝癌肝移植中获得最佳长期结果。

Obtaining Optimal Long-Term Outcomes from Liver Transplantation for Hepatocellular Cancer.

机构信息

Division of Transplant Surgery, Department of Surgery, Virginia Commonwealth University, PO Box 980057, Richmond, VA, 23298-0057, USA.

Division of Transplantation and Hepatobiliary Surgery, University of Florida, Gainesville, FL, USA.

出版信息

Dig Dis Sci. 2019 Apr;64(4):976-984. doi: 10.1007/s10620-019-05550-5.

DOI:10.1007/s10620-019-05550-5
PMID:30840163
Abstract

Liver transplantation is the definitive treatment for patients with end-stage liver disease. Liver transplantation is also the optimal treatment for patients with hepatocellular carcinoma (HCC), especially in the setting of chronic liver disease. Unfortunately, due to the worldwide shortage of organs, this treatment is not available for all patients with HCC. Strict selection criteria have been developed in order to obtain optimal results. A surgical perspective of the preoperative selection, perioperative management, and postoperative care of patients is reviewed in depth and provides an overview for obtaining optimal long-term results from liver transplantation for HCC. With rigorous selection and patient management, excellent long-term outcomes can be obtained with liver transplantation for patients with HCC.

摘要

肝移植是终末期肝病患者的确定性治疗方法。肝移植也是肝细胞癌(HCC)患者的最佳治疗方法,尤其是在慢性肝病的情况下。不幸的是,由于全球器官短缺,并非所有 HCC 患者都能接受这种治疗。为了获得最佳结果,已经制定了严格的选择标准。本文深入回顾了肝移植治疗 HCC 患者的术前选择、围手术期管理和术后护理的手术观点,并提供了获得肝移植 HCC 最佳长期结果的概述。通过严格的选择和患者管理,可以为 HCC 患者进行肝移植获得极好的长期结果。

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1
Obtaining Optimal Long-Term Outcomes from Liver Transplantation for Hepatocellular Cancer.从肝癌肝移植中获得最佳长期结果。
Dig Dis Sci. 2019 Apr;64(4):976-984. doi: 10.1007/s10620-019-05550-5.
2
Surgical resection and liver transplantation for hepatocellular carcinoma.手术切除和肝移植治疗肝细胞癌。
Clin Liver Dis. 2015 May;19(2):381-99. doi: 10.1016/j.cld.2015.01.007. Epub 2015 Mar 2.
3
Hepatocellular carcinoma recurrence pattern following liver transplantation and a suggested surveillance algorithm.肝移植后肝细胞癌复发模式及建议的监测算法
Clin Imaging. 2016 Nov-Dec;40(6):1131-1134. doi: 10.1016/j.clinimag.2016.07.002. Epub 2016 Jul 7.
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Liver transplantation for hepatocellular carcinoma on cirrhosis: strategies to avoid tumor recurrence.肝硬化肝细胞癌的肝移植:避免肿瘤复发的策略。
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Liver transplantation for hepatocellular carcinoma: indications, bridge therapy and adjuvant therapy.肝细胞癌的肝移植:适应证、过渡治疗及辅助治疗
J Okla State Med Assoc. 2012 Jan;105(1):12-6. doi: 10.1002/sta4.3.
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Developments in liver transplantation for hepatocellular carcinoma.肝癌肝移植的进展。
Semin Oncol. 2012 Aug;39(4):510-21. doi: 10.1053/j.seminoncol.2012.05.008.
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Liver transplantation for hepatocellular carcinoma: an update.肝移植治疗肝细胞癌:最新进展。
Hepatobiliary Pancreat Dis Int. 2011 Jun;10(3):234-42. doi: 10.1016/s1499-3872(11)60039-8.
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Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators.肝移植后肝细胞癌复发:术前和术后预后指标综述
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Indications and limitations of liver transplantation for hepatocellular carcinoma.肝细胞癌肝移植的适应症与局限性
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Chitosan-based biomaterial delivery strategies for hepatocellular carcinoma.用于肝细胞癌的基于壳聚糖的生物材料递送策略
Front Pharmacol. 2024 Aug 5;15:1446030. doi: 10.3389/fphar.2024.1446030. eCollection 2024.
2
Incremental value of radiomics-based heterogeneity to the existing risk criteria in predicting recurrence of hepatocellular carcinoma after liver transplantation.基于影像组学的异质性对现有风险标准在预测肝移植后肝细胞癌复发中的增量价值。
Eur Radiol. 2023 Sep;33(9):6608-6618. doi: 10.1007/s00330-023-09591-3. Epub 2023 Apr 4.
3
Recent therapeutics in hepatocellular carcinoma.

本文引用的文献

1
Liver transplantation and waitlist mortality for HCC and non-HCC candidates following the 2015 HCC exception policy change.2015 年 HCC 例外政策变更后,肝移植和 HCC 及非 HCC 候选者的候补名单死亡率。
Am J Transplant. 2019 Feb;19(2):564-572. doi: 10.1111/ajt.15144. Epub 2018 Nov 9.
2
Liver Allograft Failure After Nivolumab Treatment-A Case Report With Systematic Literature Research.纳武单抗治疗后肝移植失败——一例报告及系统文献研究
Transplant Direct. 2018 Jul 20;4(8):e376. doi: 10.1097/TXD.0000000000000814. eCollection 2018 Aug.
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Downstaging prior to liver transplantation for hepatocellular carcinoma: advisable but at the price of an increased risk of cancer recurrence - a retrospective study.
肝细胞癌的最新治疗方法
Am J Cancer Res. 2023 Jan 15;13(1):261-275. eCollection 2023.
肝癌肝移植前降期:有必要,但增加癌症复发风险 - 一项回顾性研究。
Transpl Int. 2019 Feb;32(2):163-172. doi: 10.1111/tri.13337. Epub 2018 Sep 10.
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Locoregional treatments before liver transplantation for hepatocellular carcinoma: a study from the European Liver Transplant Registry.肝移植治疗肝癌前的局部区域治疗:来自欧洲肝移植登记处的一项研究。
Transpl Int. 2018 May;31(5):531-539. doi: 10.1111/tri.13123. Epub 2018 Feb 21.
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Cancer statistics, 2018.癌症统计数据,2018 年。
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Excellent Outcomes of Liver Transplantation Following Down-Staging of Hepatocellular Carcinoma to Within Milan Criteria: A Multicenter Study.米兰标准范围内肝癌降期后肝移植的优异结果:一项多中心研究。
Clin Gastroenterol Hepatol. 2018 Jun;16(6):955-964. doi: 10.1016/j.cgh.2017.11.037. Epub 2017 Nov 23.
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Validation of the prognostic power of the RETREAT score for hepatocellular carcinoma recurrence using the UNOS database.利用 UNOS 数据库验证 RETREAT 评分对肝细胞癌复发预后的预测能力。
Am J Transplant. 2018 May;18(5):1206-1213. doi: 10.1111/ajt.14549. Epub 2017 Dec 2.
8
Downstaging therapy followed by liver transplantation for hepatocellular carcinoma beyond Milan criteria.对于超出米兰标准的肝细胞癌,先进行降期治疗,然后进行肝移植。
Surgery. 2017 Dec;162(6):1250-1258. doi: 10.1016/j.surg.2017.08.007. Epub 2017 Oct 13.
9
Systematic Review and Meta-Analysis of Posttransplant Hepatic Artery and Biliary Complications in Patients Treated With Transarterial Chemoembolization Before Liver Transplantation.肝移植术前经肝动脉化疗栓塞治疗后患者的肝动脉和胆道并发症的系统评价和荟萃分析。
Transplantation. 2018 Jan;102(1):88-96. doi: 10.1097/TP.0000000000001936.
10
Comparison of outcomes between SBRT, yttrium-90 radioembolization, transarterial chemoembolization, and radiofrequency ablation as bridge to transplant for hepatocellular carcinoma.立体定向体部放疗、钇-90放射性栓塞、经动脉化疗栓塞及射频消融作为肝细胞癌移植桥接治疗的疗效比较
Adv Radiat Oncol. 2015 Dec 29;1(1):35-42. doi: 10.1016/j.adro.2015.12.003. eCollection 2016 Jan-Mar.