Key Laboratory of Etiology and Epidemiology, National Health and Family Planning Commission, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150086, Heilongjiang, China.
The Fourth Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China.
Biol Trace Elem Res. 2020 Jan;193(1):36-43. doi: 10.1007/s12011-019-01689-4. Epub 2019 Mar 6.
The objectives of this study were to explore reference intervals of ratios of concentrations of urinary iodine to creatinine (UIC/UCr) in pregnant women, to determine specific reference intervals for thyroid hormone concentrations (FT, FT, TSH) in the first trimester of pregnancy, and provide a comprehensive evaluation of iodine nutritional status and thyroid function. Cross-sectional data analysis, including questionnaires and thyroid ultrasonograms, were used to exclude subjects who had a history of thyroid disease, a family history of thyroid disease, or thyroid morphological abnormalities. Tests of thyroid hormone were evaluated together with urinary iodine concentration (UIC), urinary creatinine concentration (UCr), and salt iodine concentration in pregnant women. For the sample of pregnant women eligible for inclusion, the 95% reference intervals of the bilateral limits of UIC/UCr and thyroid hormone concentrations in pregnant women were determined by the percentile method. Pregnant women were recruited in Harbin, Heilongjiang Province, a particular geographical area of China, where iodine nutrition is adequate. The median UIC was 141.47 μg/L, while the median UIC/UCr was 141.12 μg/g. The reference intervals of thyroid hormone concentrations in the first trimester were FT 3.63-6.12 pmol/L, FT 11.89-22.91 pmol/L, and TSH 0.013-3.814 mIU/L. The reference intervals of UIC/UCr were 52.47 to 532.09 μg/g (first trimester 47.25-353.91 μg/g, second trimester 57.95-639.08 μg/g, third trimester 46.98-494.73 μg/g).The established UIC/UCr medical reference intervals and thyroid hormone concentration reference intervals may be used for iodine nutritional assessment and thyroid disease screening in pregnant women.
本研究旨在探讨妊娠妇女尿碘与尿肌酐（UIC/UCr）比值的参考区间，确定妊娠早期甲状腺激素（FT3、FT4、TSH）的具体参考区间，并全面评估碘营养状况和甲状腺功能。采用问卷调查和甲状腺超声相结合的横断面数据分析，排除有甲状腺疾病史、甲状腺疾病家族史或甲状腺形态异常的受试者。对甲状腺激素检测结果与尿碘浓度（UIC）、尿肌酐浓度（UCr）和孕妇食盐碘浓度进行综合评估。对于符合纳入标准的妊娠妇女样本，采用百分位数法确定双侧限 UIC/UCr 和妊娠妇女甲状腺激素浓度的 95%参考区间。在碘营养充足的中国特定地理区域黑龙江省哈尔滨市招募妊娠妇女。中位 UIC 为 141.47μg/L，UIC/UCr 中位数为 141.12μg/g。妊娠早期甲状腺激素浓度参考区间为 FT33.63-6.12pmol/L、FT411.89-22.91pmol/L 和 TSH 0.013-3.814mIU/L。UIC/UCr 的参考区间为 52.47-532.09μg/g（妊娠早期 47.25-353.91μg/g，妊娠中期 57.95-639.08μg/g，妊娠晚期 46.98-494.73μg/g）。本研究建立的 UIC/UCr 医学参考区间和甲状腺激素浓度参考区间可用于妊娠妇女碘营养评估和甲状腺疾病筛查。
