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男性生育调节

Fertility regulation in the male.

作者信息

de Kretser D M

出版信息

Bull World Health Organ. 1978;56(3):353-60.

PMID:308403
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2395594/
Abstract

The current state of research into new methods of male contraception is reviewed, with special emphasis on the efforts of the WHO Special Programme of Research, Development and Research Training in Human Reproduction. The article concentrates mainly on the development of orally administered or injectable substances capable of either (a) interfering with the hormonal control of testicular function, (b) disrupting spermatogenesis by direct influence on testis function, or (c) interfering with the fertilizing ability of the sperm and their transport. It is concluded that, despite the numerous areas of research currently being pursued, the availability of a new male contraceptive remains several years away.

摘要

本文综述了男性避孕新方法的研究现状,特别强调了世界卫生组织人类生殖研究、发展和研究培训特别规划所做的努力。文章主要集中于口服或注射用物质的研发,这些物质能够:(a)干扰睾丸功能的激素控制;(b)通过直接影响睾丸功能破坏精子发生;或(c)干扰精子的受精能力及其运输。结论是,尽管目前有众多研究领域正在开展,但新型男性避孕药的问世仍需数年时间。

相似文献

1
Fertility regulation in the male.男性生育调节
Bull World Health Organ. 1978;56(3):353-60.
2
Target sites for suppressing fertility in the male.男性生育抑制的靶点
Adv Sex Horm Res. 1976;2:263-87.
3
Status of male contraception.男性避孕的现状。
Obstet Gynecol Annu. 1977;6:355-69.
4
The prospects for new, reversible male contraceptives.新型可逆性男性避孕药的前景。
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Male hormonal contraception: concept proven, product in sight?男性激素避孕:概念已获证实,产品在望?
Hum Reprod Update. 2006 Jul-Aug;12(4):463-82. doi: 10.1093/humupd/dml010. Epub 2006 Apr 5.
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Prospects for new hormonal male contraceptives.新型男性激素避孕药的前景。
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The biology of human male reproduction: an overview.人类男性生殖生物学概述
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8
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9
Regulation of primate testicular function by GnRH analogues.
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10
Male fertility regulation: recent advances.男性生育调节:最新进展
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本文引用的文献

1
Synergistic interaction of testosterone and oestradiol inhibits spermatogenesis in rats.睾酮和雌二醇的协同相互作用抑制大鼠精子发生。
Nature. 1977 Sep 29;269(5627):409-11. doi: 10.1038/269409a0.
2
The prospects for new, reversible male contraceptives.新型可逆性男性避孕药的前景。
N Engl J Med. 1976 Nov 11;295(20):1111-7. doi: 10.1056/NEJM197611112952005.
3
Guidelines for assessment of potential hepatotoxic effects of synthetic androgens, anabolic agents and progestagens in their use in males as antifertility agents.
Contraception. 1976 Apr;13(4):461-8. doi: 10.1016/s0010-7824(76)80031-5.
4
The current status of male and female sterilization procedures.男性和女性绝育手术的现状。
Proc R Soc Lond B Biol Sci. 1976 Dec 10;195(1118):93-114. doi: 10.1098/rspb.1976.0101.