Cotton Colleen H, Goldberg Gerald N
Division of Dermatology, University of Arizona College of Medicine, Tucson, Arizona.
Pima Dermatology, Tucson, Arizona.
Pediatr Dermatol. 2019 Mar;36(2):227-231. doi: 10.1111/pde.13745. Epub 2019 Mar 6.
We report on four children born with medium to large congenital melanocytic nevi (CMN) with color heterogeneity and irregular surface rugosity. As these patients aged, their nevi evolved to become more homogeneous and lighter in color, and developed a smoother, more even texture. We propose that given this evolution toward benignity, conservative monitoring and management may be appropriate even in the context of atypical-appearing features at birth. Such knowledge regarding the evolution of these CMN can more accurately guide parents and clinicians in determining whether to biopsy or remove an atypical-looking lesion early in life for medical or cosmetic reasons.
我们报告了4例出生时患有中至大型先天性黑素细胞痣（CMN）的儿童，这些痣具有颜色异质性和不规则的表面粗糙度。随着这些患者年龄的增长，他们的痣逐渐变得更加均匀、颜色变浅，并形成了更光滑、更均匀的质地。我们认为，鉴于这种向良性发展的趋势，即使在出生时出现非典型外观特征的情况下，保守监测和管理可能也是合适的。关于这些CMN演变的此类知识可以更准确地指导父母和临床医生决定是否出于医疗或美容原因在生命早期对外观异常的病变进行活检或切除。
