Galan Pilar, Hercberg Serge
Équipe de recherche en épidémiologie nutritionnelle (EREN), UMR U1153 Inserm/ U1125 Inra/Cnam/ université Paris-13, centre de recherche en épidémiologie et statistique Sorbonne-Paris- Cité, France.
Département de santé publique, hôpital Avicenne (AP-HP), Bobigny, France.
Rev Prat. 2018 Jan;68(1):37-40.
Su.vi.max and nutrinet-santé: lessons from large cohorts. This paper presents two epidemiologic studies in the field of nutrition, implemented in France for the last decades: an intervention trial (SU.VI.MAX) and a web-based prospective cohort study (NutriNet-Santé). The SU.VI.MAX study, a randomised, double-blind, placebo-controlled primary prevention trial, has shown that 7.5 years daily low-dose antioxidant supplementation (vitamins and minerals) lowered the total cancer incidence in men only, not in women. This may be explained by a lower baseline status of certain antioxidants (measured by blood concentration) in men compared to women. Finally, the effect of antioxidant supplementation on the incidence of cancer could depend on baseline antioxidant status (which differs from gender and/or nutritional status) and the health status of subjects (healthy vs cancer high-risk subjects). The NutriNet-Santé cohort is a web-based prospective cohort study launched in 2009 aiming to investigate the relationship between nutrition (nutrients, foods, dietary patterns, physical activity) and health outcomes; and to examine the determinants of dietary patterns and nutritional status (sociological, economic, cultural, biological, cognitive, perceptions, preferences, etc.).
苏维麦克斯（Su.vi.max）和营养与健康研究（Nutrinet - Santé）：大型队列研究的经验教训。本文介绍了过去几十年在法国开展的两项营养领域的流行病学研究：一项干预试验（苏维麦克斯）和一项基于网络的前瞻性队列研究（营养与健康研究）。苏维麦克斯研究是一项随机、双盲、安慰剂对照的一级预防试验，结果表明，每日低剂量补充抗氧化剂（维生素和矿物质）7.5年仅降低了男性的总体癌症发病率，对女性则无此效果。这可能是因为男性某些抗氧化剂的基线水平（通过血液浓度测量）低于女性。最后，抗氧化剂补充对癌症发病率的影响可能取决于基线抗氧化剂状态（因性别和/或营养状况而异）以及受试者的健康状况（健康人群与癌症高危人群）。营养与健康研究队列是一项于2009年启动的基于网络的前瞻性队列研究，旨在调查营养（营养素、食物、饮食模式、身体活动）与健康结果之间的关系；并研究饮食模式和营养状况的决定因素（社会学、经济、文化、生物学、认知、观念、偏好等）。
