Unité de Recherche en Epidémiologie Nutritionnelle, U Institut National de la Santeacute et de la Recherche Meacutedicale, Université Paris, Bobigny, France.
Am J Clin Nutr. 2011 Sep;94(3):892-9. doi: 10.3945/ajcn.110.007815. Epub 2011 Jul 20.
Antioxidant properties of some vitamins and trace elements may help to prevent cognitive decline.
The aim of the current study was to estimate the long-term effects of antioxidant nutrient supplementation on the cognitive performance of participants in the Supplementation in Vitamins and Mineral Antioxidants (SU.VI.MAX) study 6 y after the end of the trial.
This study included 4447 French participants aged 45-60 y who were enrolled in the SU.VI.MAX study (1994-2002), which was a double-blind, placebo-controlled, randomized trial. From 1994 to 2002, participants received daily vitamin C (120 mg), β-carotene (6 mg), vitamin E (30 mg), selenium (100 μg), and zinc (20 mg) in combination or as a placebo. In 2007-2009, the cognitive performance of participants was assessed with 4 neuropsychological tests (6 tasks). Principal components analysis (PCA) was performed to identify cognitive-function summary scores. Associations between antioxidant supplementation and cognitive functions, in the full sample and by subgroups, were estimated through ANOVA and expressed as mean differences and 95% CIs. Subgroup analyses were performed according to baseline characteristics.
Subjects receiving active antioxidant supplementation had better episodic memory scores (mean difference: 0.61; 95% CI: 0.02, 1.20). PCA indicated 2 factors that were interpreted as showing verbal memory and executive functioning. Verbal memory was improved by antioxidant supplementation only in subjects who were nonsmokers or who had low serum vitamin C concentrations at baseline.
This study supports the role of an adequate antioxidant nutrient status in the preservation of verbal memory under certain conditions. This trial was registered at clinicaltrials.gov as NCT00272428.
一些维生素和微量元素的抗氧化特性可能有助于预防认知能力下降。
本研究旨在评估抗氧化营养素补充对 SU.VI.MAX 研究结束 6 年后参与者认知表现的长期影响。
本研究纳入了 4447 名年龄在 45-60 岁的法国参与者，他们参加了 SU.VI.MAX 研究（1994-2002 年），这是一项双盲、安慰剂对照、随机试验。1994 年至 2002 年期间，参与者每天服用维生素 C（120mg）、β-胡萝卜素（6mg）、维生素 E（30mg）、硒（100μg）和锌（20mg），或安慰剂。2007-2009 年，通过 4 项神经心理学测试（6 项任务）评估参与者的认知表现。进行主成分分析（PCA）以确定认知功能综合评分。通过方差分析（ANOVA）评估抗氧化补充剂与认知功能之间的关系，并以均值差异和 95%置信区间（CI）表示。根据基线特征进行亚组分析。
接受活性抗氧化补充剂的受试者的情景记忆评分较高（平均差异：0.61；95%CI：0.02，1.20）。PCA 表明有 2 个因素，可解释为显示出言语记忆和执行功能。只有在基线时不吸烟或血清维生素 C 浓度较低的受试者中，抗氧化补充剂才改善了言语记忆。
本研究支持在某些条件下，充足的抗氧化营养素状态对保持言语记忆的作用。该试验在 clinicaltrials.gov 注册，编号为 NCT00272428。
