用于药物释放的 α-壳聚糖纳米线-聚乙烯醇水凝胶的制备。
The preparation of α-chitin nanowhiskers-poly (vinyl alcohol) hydrogels for drug release.
机构信息
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China.
出版信息
Int J Biol Macromol. 2019 Jun 15;131:336-342. doi: 10.1016/j.ijbiomac.2019.03.015. Epub 2019 Mar 3.
A series of highly porous and biocompatible poly (vinyl alcohol) (PVA) hydrogels containing partially deacetylated α-chitin nanowhiskers (ChWs) were fabricated by the double-cross-link (DC) with glutaraldehyde (GA) and repeating freeze-thawing cycle. Then these hydrogels were used as carrier for bovine serum albumin (BSA), which served as the model drug. The nanowhiskers worked effectively to raise the mechanical property of the PVA/ChWs hydrogels. This property increased significantly from 1.55 to 26.59 MPa with the increase of the ratio of ChWs to PVA from 0% to 40%. Additionally, the morphological properties of the gel matrix were comprehensively investigated. The results showed that the novel ChWs/PVA hydrogels were facilely constructed from sequential chemical cross-linking and physical cross-linking with GA. The hydrogel with the ChWs to PVA weight ratios of 40% achieved the highest equilibrium swelling ratio, and could release more than 80% of the BSA from its gel matrix within 75 h.
一系列具有高度多孔性和生物相容性的含有部分脱乙酰化 α-壳聚糖纳米纤维（ChWs）的聚（乙烯醇）（PVA）水凝胶是通过戊二醛（GA）的双交联（DC）和重复冻融循环制备的。然后，这些水凝胶被用作牛血清白蛋白（BSA）的载体，BSA 用作模型药物。纳米纤维有效地提高了 PVA/ChWs 水凝胶的机械性能。随着 ChWs 与 PVA 比例从 0%增加到 40%，这种性能从 1.55 MPa 显著提高到 26.59 MPa。此外，还全面研究了凝胶基质的形态特性。结果表明，新型 ChWs/PVA 水凝胶是通过 GA 的顺序化学交联和物理交联轻松构建的。ChWs 与 PVA 的重量比为 40%的水凝胶达到了最高的平衡溶胀比，并且可以在 75 小时内从其凝胶基质中释放超过 80%的 BSA。
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