深入了解皮肤衰老与抗感染免疫
"Deepening" Insight on Skin Aging and Anti-microbial Immunity.
机构信息
Cutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
Cutaneous Leukocyte Biology Section, Dermatology Branch, NIAMS, NIH, Bethesda, MD 20892, USA.
出版信息
Cell Metab. 2019 Mar 5;29(3):515-517. doi: 10.1016/j.cmet.2019.02.006.
PMID:30840910
Abstract
Skin aging is of considerable interest from various perspectives, ranging from aesthetics to cancer development. Zhang et al. (2019) elucidate an immunological consequence of aging in the adipose layer of skin. Age-dependent increases in TGF-β signaling impair fibroblast adipogenic potential that results in impaired anti-bacterial host defense.
摘要
皮肤衰老从各个角度来看都具有相当大的意义，包括美学和癌症发展。Zhang 等人（2019 年）阐明了皮肤脂肪层衰老的免疫学后果。随年龄增长 TGF-β 信号的增加损害了成纤维细胞的脂肪生成潜力，导致抗细菌宿主防御受损。
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