Moyer M P, Armstrong A, Parra J, Escobar D
Clin Exp Metastasis. 1986 Jan-Mar;4(1):63-70. doi: 10.1007/BF00053474.
Growth of the murine hepatoma H6 was significantly suppressed by amiloride, a sodium influx inhibitor. Primary tumor growth inhibition was augmented by loading the drug into cross-linked albumin carriers, but lung metastases were enhanced. These results emphasize the importance of using metastatic tumor models when testing new drugs and/or alternative modes of drug delivery.
