Department of Public Health, Chang Gung University, Taoyuan, Taiwan.
Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan, Taiwan.
Cancer Prev Res (Phila). 2019 Apr;12(4):247-254. doi: 10.1158/1940-6207.CAPR-18-0449. Epub 2019 Mar 6.
Multiple primary tumors (MPT), especially in the hypopharynx and esophagus, are challenging in patients with head and neck cancer (HNC). Alcohol and alcohol-metabolizing genes were reported to be related to upper digestive tract cancers. Here, we investigated whether the genotypes of alcohol-metabolizing enzymes (ADH1B, ADH1C, and ALDH2) affected patients' susceptibility to developing MPTs. We recruited 659 male patients with HNC between March 1996 and February 2017. Age- and gender-matched controls were also recruited. A total of 164 patients with HNC were identified to have second or third malignancies. The single-nucleotide polymorphisms in (rs1229984), (rs698), and (rs671) were analyzed by TaqMan assays. The prevalence of allele carriers is significantly higher than that of homozygotes for oral cavity ( = 0.013) and oropharyngeal cancers ( = 0.012). For , the number of allele carriers is significantly higher than that of homozygotes for oropharyngeal ( = 0.017) and hypopharyngeal cancers ( < 0.001). (rs698) SNPs are not significantly associated with tumor subsites (all > 0.05). Polymorphisms in ( allele carriers) and ( allele carriers) significantly increase the risk of developing MPTs in the upper digestive tract [ < 0.001, OR (95% confidence interval (CI): 5.186 (2.444-11.004) and < 0.05, OR (95% CI): 2.093 (1.149-3.812), respectively]. (rs671) and (rs1229984) allele carriers were shown to develop MPTs in the upper digestive tract. Genetic information may be used to identify high-risk patients for the development of MPTs.
多原发肿瘤（MPT），尤其是在咽和食管，是具有挑战性的在头颈部癌症（HNC）患者。酒精和酒精代谢基因被报道与上消化道癌症有关。在这里，我们研究了酒精代谢酶（ADH1B、ADH1C 和 ALDH2）的基因型是否影响患者发生 MPT 的易感性。我们招募了 1996 年 3 月至 2017 年 2 月期间的 659 名男性 HNC 患者。还招募了年龄和性别匹配的对照组。共发现 164 例 HNC 患者患有第二或第三恶性肿瘤。通过 TaqMan 检测分析了 （rs1229984）、 （rs698）和 （rs671）中的单核苷酸多态性。口腔癌（=0.013）和口咽癌（=0.012）的携带者等位基因的患病率明显高于 纯合子。对于 ，携带者等位基因的数量明显高于 纯合子口咽癌（=0.017）和下咽癌（<0.001）。 （rs698）SNP 与肿瘤亚部位无显著相关性（均>0.05）。 （等位基因携带者）和 （等位基因携带者）的多态性显著增加了上消化道发生 MPT 的风险[<0.001，OR（95%置信区间（CI）：5.186（2.444-11.004）和<0.05，OR（95%CI）：2.093（1.149-3.812）]。 （rs671）和 （rs1229984）等位基因携带者在上消化道发生 MPT。遗传信息可用于识别发生 MPT 的高危患者。
