Hidaka Akihisa, Sasazuki Shizuka, Matsuo Keitaro, Ito Hidemi, Sawada Norie, Shimazu Taichi, Yamaji Taiki, Iwasaki Motoki, Inoue Manami, Tsugane Shoichiro
Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan.
Epidemiology and Prevention Group, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo 104-0045, Japan,
Carcinogenesis. 2015 Feb;36(2):223-31. doi: 10.1093/carcin/bgu244. Epub 2014 Dec 18.
The association between alcohol consumption, genetic polymorphisms of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) and gastric cancer risk is not completely understood. We investigated the association between ADH1B (rs1229984), ADH1C (rs698) and ALDH2 (rs671) polymorphisms, alcohol consumption and the risk of gastric cancer among Japanese subjects in a population-based, nested, case-control study (1990-2004). Among 36 745 subjects who answered the baseline questionnaire and provided blood samples, 457 new gastric cancer cases matched to 457 controls were used in the analysis. The odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated using logistic regression models. No association was observed between alcohol consumption, ADH1B (rs1229984), ADH1C (rs698) and ALDH2 (rs671) polymorphisms and gastric cancer risk. However, considering gene-environmental interaction, ADH1C G allele carriers who drink ≥150 g/week of ethanol had a 2.5-fold increased risk of gastric cancer (OR = 2.54, 95% CI = 1.05-6.17) relative to AA genotype carriers who drink 0 to <150 g/week (P for interaction = 0.02). ALDH2 A allele carriers who drink ≥150 g/week also had an increased risk (OR = 2.08, 95% CI = 1.05-4.12) relative to GG genotype carriers who drink 0 to < 150 g/week (P for interaction = 0.08). To find the relation between alcohol consumption and gastric cancer risk, it is important to consider both alcohol consumption level and ADH1C and ALDH2 polymorphisms.
饮酒、酒精脱氢酶（ADH）和乙醛脱氢酶（ALDH）的基因多态性与胃癌风险之间的关联尚未完全明确。我们在一项基于人群的巢式病例对照研究（1990 - 2004年）中，调查了日本受试者中ADH1B（rs1229984）、ADH1C（rs698）和ALDH2（rs671）基因多态性、饮酒与胃癌风险之间的关联。在36745名回答了基线问卷并提供血样的受试者中，选取457例新诊断的胃癌病例及其匹配的457例对照进行分析。使用逻辑回归模型计算比值比（OR）及相应的95%置信区间（CI）。未观察到饮酒、ADH1B（rs1229984）、ADH1C（rs698）和ALDH2（rs671）基因多态性与胃癌风险之间存在关联。然而，考虑基因 - 环境相互作用时，每周饮用乙醇≥15〇g的ADH1C G等位基因携带者患胃癌的风险相较于每周饮用〇至<15〇g的AA基因型携带者增加了2.5倍（OR = 2.54，95% CI = 1.05 - 6.17）（相互作用P值= 0.02）。每周饮用乙醇≥15〇g的ALDH2 A等位基因携带者相较于每周饮用〇至<15〇g的GG基因型携带者，患癌风险也有所增加（OR = 2.08，95% CI = 1.05 - 4.12）（相互作用P值= 0.08）。要探究饮酒与胃癌风险之间的关系，同时考虑饮酒水平以及ADH1C和ALDH2基因多态性非常重要。
