诱导多能干细胞相关基因与口腔鳞状细胞癌的不良预后相关。

Induced Pluripotent Stem Cell-related Genes Correlate With Poor Prognoses of Oral Squamous Cell Carcinoma.

作者信息

Muraki Yumi, Hasegawa Takumi, Takeda Daisuke, Ueha Takeshi, Iwata Eiji, Saito Izumi, Amano Rika, Sakakibara Akiko, Akashi Masaya, Komori Takahide

机构信息

Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

Department of Oral and Maxillofacial Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

出版信息

Anticancer Res. 2019 Mar;39(3):1205-1216. doi: 10.21873/anticanres.13231.

DOI:10.21873/anticanres.13231

PMID:30842151

Abstract

BACKGROUND/AIM: We recently investigated the contribution of the iPS-related genes SOX2, OCT4, and Nanog to de-differentiation by assaying for their mRNA levels. Given that mRNA expression does not always correlate with the protein levels, the aim of this study was to retrospectively determine the expression of these four iPS-related factors in human OSCC specimens by immunohistochemistry and examine their association with patient prognosis.

MATERIALS AND METHODS

iPS cell-related gene expression in 89 OSCC patients by tissue microarray, and its correlation with clinicopathological factors, differentiation, metastasis, and poor prognoses were investigated.

RESULTS

No evidence of statistically significant relationships was found between the expression of iPS cell-related genes and clinicopathological parameters. However, our data indicated that KLF4 expression was associated with survival, and poor tumor differentiation. In addition, high expression of KLF4 was an independent poor prognostic factor (p=0.004) for OSCC patients.

CONCLUSION

In preoperative biopsies, higher KLF4 and poor differentiation may be clinically effective predictors for the prognosis of oral cancer.

摘要

背景/目的：我们最近通过检测其mRNA水平，研究了诱导多能干细胞（iPS）相关基因SOX2、OCT4和Nanog对去分化的作用。鉴于mRNA表达并不总是与蛋白质水平相关，本研究的目的是通过免疫组织化学回顾性确定这四种iPS相关因子在人口腔鳞状细胞癌（OSCC）标本中的表达，并研究它们与患者预后的关系。