锌对人T细胞的单核细胞依赖性刺激

Monocyte-dependent stimulation of human T cells by zinc.

作者信息

Rühl H, Kirchner H

出版信息

Clin Exp Immunol. 1978 Jun;32(3):484-8.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1541339/

Abstract

Subpopulations of human peripheral blood leucocytes were isolated by nylon filtration or E-rosette separation and tested for functional activity. As shown previously, zinc ions induce DNA synthesis in unfractionated lymphocyte cultures. E-rosette-forming cells (E-RFC), obtained either by nylon wool filtration or E-rosette separation, responded well to PHA but showed only low levels of proliferative reactivity to zinc and Con A. These dminished responses could be completely restored by the addition of small numbers of autologous, mitomycin-treated monocytes; further experiments suggested that a monocyte-derived soluble factor can substitute for monocytes in this function. B lymphocyte-enriched cell populations, containing less than 1% E-RFC, did not respond to zinc and showed only marginal reactivity to PHA and Con A.

摘要

通过尼龙过滤或E花环分离法分离人外周血白细胞亚群，并检测其功能活性。如先前所示，锌离子可诱导未分级淋巴细胞培养物中的DNA合成。通过尼龙棉过滤或E花环分离获得的E花环形成细胞（E-RFC）对PHA反应良好，但对锌和刀豆球蛋白A的增殖反应水平较低。加入少量经丝裂霉素处理的自体单核细胞可完全恢复这些减弱的反应；进一步的实验表明，单核细胞衍生的可溶性因子可在该功能中替代单核细胞。富含B淋巴细胞的细胞群体，其E-RFC含量低于1%，对锌无反应，对PHA和刀豆球蛋白A仅表现出微弱反应。

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本文引用的文献

1

Kinetics of the Zn 2+ - stimulation of human peripheral lmphocytes in vitro.体外锌离子对人外周淋巴细胞刺激作用的动力学

Proc Soc Exp Biol Med. 1971 Jul;137(3):1089-92.

2

Lymphocyte reactivity in vitro. II. Soluble reconstituting factor permitting response of purified lymphocyte.淋巴细胞体外反应性。II. 使纯化淋巴细胞产生反应的可溶性重组因子。

Cell Immunol. 1970 Jul;1(2):219-27. doi: 10.1016/0008-8749(70)90009-2.

3

Stimulation of human peripheral lymphocytes by Zn2+ in vitro.锌离子（Zn2+）体外刺激人外周血淋巴细胞

Exp Cell Res. 1970 Jul;61(1):229-30. doi: 10.1016/0014-4827(70)90284-3.

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The effect of zinc on calves with hereditary thymus hypoplasia (lethal trait A 46).

Acta Pathol Microbiol Scand A. 1971;79(6):686-7. doi: 10.1111/j.1699-0463.1971.tb01873.x.

5

Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).T淋巴细胞对丝裂原反应的增强作用。II. 增强介质的细胞来源。

J Exp Med. 1972 Jul 1;136(1):143-55. doi: 10.1084/jem.136.1.143.

6

Potentiation of the T-lymphocyte response to mitogens. I. The responding cell.T淋巴细胞对丝裂原反应的增强作用。I. 反应细胞。

J Exp Med. 1972 Jul 1;136(1):128-42. doi: 10.1084/jem.136.1.128.

7

Functional heterogeneity of murine lymphoid cells. I. Responsiveness to and surface binding of concanavalin A and phytohemagglutinin.小鼠淋巴细胞的功能异质性。I. 对刀豆球蛋白A和植物血凝素的反应性及表面结合

J Immunol. 1972 Jan;108(1):1-17.

8

Potentiation of cultured mouse thymocyte responses by factors released by peripheral leucocytes.外周白细胞释放的因子对培养的小鼠胸腺细胞反应的增强作用。

J Immunol. 1971 Dec;107(6):1778-80.

9

Selective triggering of human T and B lymphocytes in vitro by polyclonal mitogens.多克隆有丝分裂原在体外对人T和B淋巴细胞的选择性触发

J Exp Med. 1974 Jul 1;140(1):1-18. doi: 10.1084/jem.140.1.1.

10

Chronic lymphocytic leukemia cells: rosette formation and adherence to nylon fiber columns.慢性淋巴细胞白血病细胞：玫瑰花结形成及对尼龙纤维柱的黏附

J Natl Cancer Inst. 1974 Jan;52(1):13-7. doi: 10.1093/jnci/52.1.13.

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