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[具有潜在血小板抗聚集活性的2-亚芳基-3,4-二氢-1（2H）-萘酮：合成、结构与药理研究]

[2-Arylidene 3,4-dihydro-1 (2H)-naphthalenones with potential platelet anti-aggregating activity: synthesis and structural and pharmacologic study].

作者信息

Varache-Beranger M, Nuhrich A, Devaux G, H'Naifi A, Carpy A

出版信息

Farmaco Sci. 1986 Feb;41(2):156-67.

PMID:3084294
Abstract

New 3,4-dihydro-2-arylidene-1-(2H)-naphthalenones derivatives were synthesized and their inhibitory effects in vitro on the arachidonic acid-induced platelet aggregation were evaluated. The 3,4-dihydro-2-[(2,5-dimethoxyphenyl)methylene]-1-(2H)-naphthalenone++ + exhibits the most potent antiaggregating activity; compared with aspirin this compound is three times more active. Its crystal structure has been determined.

摘要

合成了新型3,4-二氢-2-亚芳基-1-(2H)-萘酮衍生物，并评估了它们在体外对花生四烯酸诱导的血小板聚集的抑制作用。3,4-二氢-2-[(2,5-二甲氧基苯基)亚甲基]-1-(2H)-萘酮表现出最强的抗聚集活性；与阿司匹林相比，该化合物的活性高三倍。已确定其晶体结构。

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