Dupin J P, Gravier D, Casadebaig F, Boisseau M R, Bernard H
Farmaco Sci. 1986 Dec;41(12):934-41.
A dozen acetoxy benzene derivatives (mono- or diacetylated diphenols) were tested for inhibitory activity on platelet aggregation in human platelet rich plasma induced with collagen, ADP and arachidonic acid. All the compounds tested showed an activity, and the results emphasize the antiaggregant properties of diacetylated derivatives which are more potent than aspirin. Unlike aspirin, their action is not prevented by salicylate. However, the large inhibition of serotonin release and thromboxane synthesis localizes their activity in arachidonic acid metabolism.
测试了十二种乙酰氧基苯衍生物（单乙酰化或二乙酰化二酚）对胶原、ADP和花生四烯酸诱导的人富血小板血浆中血小板聚集的抑制活性。所有测试的化合物均表现出活性，结果强调了二乙酰化衍生物的抗聚集特性，其比阿司匹林更有效。与阿司匹林不同，水杨酸盐不会阻止它们的作用。然而，对血清素释放和血栓素合成的大量抑制将它们的活性定位在花生四烯酸代谢中。
