Samanta Sadhanendu, Hajra Alakananda
Department of Chemistry , Visva-Bharati (A Central University) , Santiniketan 731235 , India.
J Org Chem. 2019 Apr 5;84(7):4363-4371. doi: 10.1021/acs.joc.9b00366. Epub 2019 Mar 13.
A Mn(II)-catalyzed efficient C-H alkylation of imidazoheterocycles and N-heteroarenes with aliphatic aldehydes has been developed via oxidative decarbonylation. Other alkylating agents such as cyclic alkanes, ethers, and alcohols also coupled with N-heteroarenes through cross-dehydrogenative coupling. Regioselectively C5-alkylated imidazoheterocycles were synthesized in good yields. Experimental results show that radical pathway might be involved in this reaction.
通过氧化脱羰反应，已开发出一种锰（II）催化的咪唑杂环和N-杂芳烃与脂肪醛的高效C-H烷基化反应。其他烷基化剂，如环烷烃、醚和醇，也通过交叉脱氢偶联与N-杂芳烃偶联。以良好的产率合成了区域选择性C5-烷基化的咪唑杂环。实验结果表明，该反应可能涉及自由基途径。
