First Department of Internal Medicine, University of Pavia, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Gastroenterology and Endoscopy Unit, Fondazione IRCCS Cà Granda, Ospedale Policlinico di Milano, Milan, Italy; Department of Pathophysiology, Department of Transplantation, University of Milan, Milan, Italy.
Autoimmun Rev. 2019 May;18(5):549-555. doi: 10.1016/j.autrev.2019.03.012. Epub 2019 Mar 4.
Interleukin (IL)-13 is a cytokine playing a pivotal role in T helper (Th)2 immune response supposed to be implicated in some intestinal disorders. IL-13 is produced by Th2 cells, natural killer T cell, innate lymphoid cells and innate immune cells, which contribute to trigger and maintain a chronic idiopathic intestinal inflammation. In murine models IL-13 exerts pleiotropic functions, playing either pathogenic or protective roles according to the different experimental conditions. As regards celiac disease, IL-13 is considered to be involved mostly in the refractory phase rather than at uncomplicated stage. Discrepancies have been observed in the role of IL-13 upon the inflammation and fibrosis in ulcerative colitis (UC) and in Crohn's disease, respectively. Failure of the anti-IL-13 monoclonal antibodies tralokinumab and anrukinzumab in UC patients in clinical trials support the absence of a role for IL-13 in UC. This review deals with IL-13 in several experimental colitis models -such as oxazolone-, trinitrobenzene sulfonic acid- or dextran sodium sulphate-induced colitis- and chronic intestinal inflammatory disorders -including celiac disease, UC and Crohn's disease-, and it also highlights the attempts to modulate IL-13 as therapeutic tool.
白细胞介素 (IL)-13 是一种细胞因子，在 T 辅助 (Th)2 免疫反应中起着关键作用，被认为与一些肠道疾病有关。IL-13 由 Th2 细胞、自然杀伤 T 细胞、固有淋巴细胞和固有免疫细胞产生，有助于引发和维持慢性特发性肠道炎症。在小鼠模型中，IL-13 发挥多种功能，根据不同的实验条件，发挥致病或保护作用。关于乳糜泻，IL-13 被认为主要涉及难治性阶段，而不是在无并发症阶段。在溃疡性结肠炎 (UC) 和克罗恩病中，IL-13 在炎症和纤维化中的作用存在差异。在临床试验中，抗 IL-13 单克隆抗体 tralokinumab 和 anrukinzumab 在 UC 患者中的失败支持 IL-13 在 UC 中不起作用。这篇综述涉及几种实验性结肠炎模型中的 IL-13，如氧化偶氮甲烷、三硝基苯磺酸或葡聚糖硫酸钠诱导的结肠炎，以及慢性肠道炎症性疾病，包括乳糜泻、溃疡性结肠炎和克罗恩病，并强调了尝试调节 IL-13 作为治疗工具的努力。
