Center for Reproductive Medicine, Reproductive Hospital, Shandong University, 324 JingWu Road, Jinan 250021, China.
Center for Reproductive Medicine, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China,
Front Biosci (Landmark Ed). 2019 Mar 1;24(4):750-764. doi: 10.2741/4748.
Accumulating data from large-scale transcriptome studies have identified a class of poorly understood non-protein-coding RNAs, including microRNAs, piwi-interacting RNAs (piRNAs), and long non-coding RNAs (lncRNAs), and a number of studies suggest that lncRNAs modulate the expression of protein-coding genes in a variety of tissues and organs by altering chromatin modification, transcription, mRNA decay, protein subcellular localization, and other key processes. Although much work still remains to identify the roles of lncRNAs in reproduction-related systems, they are likely to exert widespread effects during these processes. In this review, we highlight our emerging understanding of how lncRNAs regulate gene expression, and we discuss the physiological role of this new class of molecular regulators in neurobiology, cardiology, endocrinology, metabolism, muscle biology, and female reproductive disorders.
越来越多的大规模转录组研究数据鉴定出了一类功能尚不明确的非编码 RNA，包括 microRNAs、piwi 相互作用 RNA（piRNAs）和长非编码 RNA（lncRNAs）。多项研究表明，lncRNAs 通过改变染色质修饰、转录、mRNA 降解、蛋白质亚细胞定位和其他关键过程来调节多种组织和器官中蛋白质编码基因的表达。尽管在鉴定 lncRNAs 在与生殖相关的系统中的作用方面仍有许多工作要做，但它们在这些过程中可能会产生广泛的影响。在这篇综述中，我们重点介绍了我们对 lncRNAs 如何调节基因表达的认识，并讨论了这类新的分子调节剂在神经生物学、心脏病学、内分泌学、代谢、肌肉生物学和女性生殖障碍中的生理作用。
