Department of Gynecology, The First Affiliated Hospital of Shenzhen University, Health Science Center, Shenzhen Second People's Hospital, 3002 Sungang West Road, Futian District, Shenzhen, 518000, Guangdong province, China.
Key Laboratory of Anti-Inflammatory and Immune Medicine, Ministry of Education, Anhui Collaborative Innovation Center of Anti-Inflammatory and Immune Medicine, Institute of Clinical Pharmacology, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui province, China.
J Ovarian Res. 2020 Jun 5;13(1):63. doi: 10.1186/s13048-020-00663-2.
Granulosa cells (GCs) are somatic cells surrounding oocytes within follicles and are essential for folliculogenesis. Pathological changes in GCs are found in several ovarian disorders. Recent reports have indicated that long non-coding RNAs (lncRNAs), which modulate gene expression via multiple mechanisms, are key regulators of the normal development of GCs, follicles, and ovaries. In addition, accumulating evidence has suggested that lncRNAs can be utilized as biomarkers for the diagnosis and prognosis of GC-related diseases, such as polycystic ovary syndrome (PCOS) and premature ovarian insufficiency (POI). Therefore, lncRNAs not only play a role in GCs that are involved in normal folliculogenesis, but they may also be considered as potential candidate biomarkers and therapeutic targets in GCs under pathological conditions. In the future, a detailed investigation of the in vivo delivery or targeting of lncRNAs and large-cohort-validation of the clinical applicability of lncRNAs is required.
颗粒细胞（GCs）是围绕卵泡内卵母细胞的体细胞，对于卵泡发生至关重要。GCs 的病理变化存在于几种卵巢疾病中。最近的报告表明，长非编码 RNA（lncRNAs）通过多种机制调节基因表达，是 GCs、卵泡和卵巢正常发育的关键调节剂。此外，越来越多的证据表明，lncRNAs 可用作与 GC 相关疾病（如多囊卵巢综合征（PCOS）和卵巢早衰（POI））的诊断和预后的生物标志物。因此，lncRNAs 不仅在参与正常卵泡发生的 GCs 中发挥作用，而且在病理条件下的 GCs 中也可以被视为潜在的候选生物标志物和治疗靶点。未来需要对 lncRNAs 的体内递药或靶向进行详细研究，并对 lncRNAs 的临床适用性进行大样本队列验证。
