Brand Caroline, Leite Neiva, Lopes Wendell Arthur, Dias Arieli Fernandes, da Silva Larissa Rosa, Araujo Gaya Adroaldo Cezar, Mota Jorge, Cavaglieri Claudia Regina, Gaya Anelise Reis
Project Sport Brazil (PROESP-Br), Post Graduation Program in Human Movement Sciences, School of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Street: Felizardo, 750, Felizardo Street, Jardim Botânico, Porto Alegre, Brazil.
Research Center on Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto, Porto, Portugal, Phone: +55 (51) 3308.5883.
J Pediatr Endocrinol Metab. 2019 Mar 26;32(3):239-246. doi: 10.1515/jpem-2018-0407.
Background Cardiorespiratory fitness (CRF) and pubertal stages have been related to many health outcomes, including obesity and adipocytokines. Thus, the present study aimed to analyze the moderator role of CRF and pubertal stage in the relationship between adiposity and adipocytokines in girls. Method This cross-sectional study was performed with 42 pre-pubertal girls aged from 7 to 11 years and 54 post-pubertal girls aged from 13 to 17 years. Blood samples were collected to determine the serum levels of leptin and adiponectin, and then the leptin/adiponectin ratio (L/A ratio) was calculated. CRF, anthropometric and body composition indicators were assessed. For statistical analysis, descriptive statistics and several linear regression models were used. The moderation analysis was tested using the PROCESS macro. Results An interaction between body mass index (BMI) and CRF (β: -0.70; confidence interval [CI]: -1.29, -0.12), as well as between BMI and pubertal stage (β: 0.79; CI: 0.28, 1.30) with leptin, was found. Regarding the L/A ratio, an interaction was found only in BMI × CRF (β: -0.56; CI: -1.06, -0.06). Using a combined interaction (CRF and pubertal stage), the results showed a positive association between BMI with leptin and L/A ratio only in low CRF, pre-pubertal and post-pubertal stages. Conclusion This study suggests a protective role of high levels of CRF in the relationship between BMI and adipocytokines. Despite the effect of pubertal stage, the results suggest that youth should be engaged in physical activity in order to improve CRF levels and consequently improve cardiometabolic health.
心肺适能（CRF）和青春期阶段与许多健康结局相关，包括肥胖和脂肪细胞因子。因此，本研究旨在分析CRF和青春期阶段在女孩肥胖与脂肪细胞因子关系中的调节作用。方法：本横断面研究对42名7至11岁的青春期前女孩和54名13至17岁的青春期后女孩进行。采集血样以测定瘦素和脂联素的血清水平，然后计算瘦素/脂联素比值（L/A比值）。评估CRF、人体测量学和身体成分指标。进行统计分析时，使用了描述性统计和几个线性回归模型。使用PROCESS宏进行调节分析。结果：发现体重指数（BMI）与CRF之间存在交互作用（β：-0.70；置信区间[CI]：-1.29，-0.12），BMI与青春期阶段之间也存在交互作用（β：0.79；CI：0.28，1.30），且与瘦素有关。关于L/A比值，仅在BMI×CRF中发现交互作用（β：-0.56；CI：-1.06，-0.06）。使用联合交互作用（CRF和青春期阶段），结果显示仅在低CRF、青春期前和青春期后阶段，BMI与瘦素和L/A比值之间存在正相关。结论：本研究表明高水平的CRF在BMI与脂肪细胞因子的关系中具有保护作用。尽管青春期阶段有影响，但结果表明青少年应进行体育活动以提高CRF水平，从而改善心脏代谢健康。
