Immunonutrition Research Group, Department of Metabolism and Nutrition, Institute Frio- Institute of Food Science, Technology and Nutrition-ICTAN, Spanish National Research Council- CSIC, Madrid, Spain.
Nutr Metab Cardiovasc Dis. 2012 Mar;22(3):252-9. doi: 10.1016/j.numecd.2010.07.010. Epub 2011 Jan 28.
Adipocytokines may have a key role in the development of atherosclerosis and type 2 diabetes. The purpose of this study was to examine the independent and joint associations of physical activity (PA), cardiorespiratory fitness (CRF) and muscular fitness (MF) with adiponectin and leptin in adolescents.
A sample of 198 adolescents (96 girls), aged 13-17-year, was selected. Participants completed anthropometric measurements (height, weight, and waist circumference) and percentage of body fat (%BF) was estimated by bioelectrical impedance. PA was measured by accelerometer for 7-day. The 20-m shuttle-run test was used to assess CRF and two MF tests (handgrip strength and standing broad jump) were used to create an MF score. A cluster score of health status (0-3 risks) was created. Serum adiponectin and plasma leptin were also determined. Regression analyses controlling for age, sex, pubertal status and waist circumference showed that PA was not significantly associated with adiponectin and vigorous PA showed a significant inverse association with leptin. Both CRF and MF were significantly and inversely associated with adiponectin and leptin. Further analyses revealed that the 'healthy' group (0 risks) had significantly lower adiponectin and leptin than 'medium-healthy' (1 risk) and 'unhealthy' (2-3 risks) status groups.
PA, CRF and MF are inversely and jointly associated with adiponectin and leptin concentrations in adolescents.
脂肪细胞因子在动脉粥样硬化和 2 型糖尿病的发展中可能具有关键作用。本研究的目的是研究体力活动（PA）、心肺功能（CRF）和肌肉力量与青少年脂联素和瘦素的独立和联合关联。
选择了 198 名 13-17 岁的青少年（96 名女孩）作为样本。参与者完成了人体测量学测量（身高、体重和腰围），并通过生物电阻抗法估计体脂肪百分比（%BF）。PA 通过加速度计进行 7 天测量。20 米往返跑测试用于评估 CRF，两项肌肉力量测试（握力和立定跳远）用于创建肌肉力量评分。创建了一个健康状况的聚类评分（0-3 个风险）。还测定了血清脂联素和血浆瘦素。控制年龄、性别、青春期状态和腰围的回归分析显示，PA 与脂联素无显著相关性，剧烈 PA 与瘦素呈显著负相关。CRF 和 MF 与脂联素和瘦素均呈显著负相关。进一步分析显示，“健康”组（0 个风险）的脂联素和瘦素明显低于“中等健康”（1 个风险）和“不健康”（2-3 个风险）状态组。
PA、CRF 和 MF 与青少年脂联素和瘦素浓度呈负相关和共同相关。
