Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.
Division of Pathophysiology, Department of Pathophysiology and Endocrinology, Medical University of Silesia, Zabrze, Poland.
Endokrynol Pol. 2019;70(4):336-341. doi: 10.5603/EP.a2019.0013. Epub 2019 Mar 7.
The predominance of high-molecular-weight forms of prolactin in plasma is referred to as macroprolactinaemia. Unlike monomeric hyperprolactinaemia, no previous study has investigated cardiometabolic risk factors in subjects with elevated macroprolactin content.
We studied two age-, weight-, and blood pressure-matched groups of premenopausal women: 11 women with macroprolactinaemia and 11 women with prolactin levels within the reference range. The outcomes of interest included: glucose homeostasis markers, plasma lipids, as well as plasma levels of uric acid, high-sensitivity C-reactive protein (hsCRP), fibrinogen, homocysteine, and 25-hydroxyvitamin D.
Circulating levels of hsCRP and 2-h postchallenge plasma glucose, as well as the homeostatic model assessment 1 of insulin resistance ratio, were higher, while levels of HDL cholesterol and 25-hydroxyvitamin D were lower in women with macroprolactinaemia than in women without elevated levels of prolactin. In women with elevated levels of big-big prolactin, values of hsCRP and 25-hydroxyvitamin D correlated with the degree of insulin resistance and, similarly to HDL cholesterol and 2-h postchallenge plasma glucose, with macroprolactin content. There were no differences between the study groups in concentrations of fasting glucose, total cholesterol, LDL cholesterol, triglycerides, uric acid, fibrinogen, and homocysteine.
The obtained results indicate that young women with macroprolactinaemia seem to be characterised by slightly increased cardiometabolic risk.
血浆中高分子量形式的催乳素占优势被称为巨泌乳素血症。与单体性高催乳素血症不同，以前没有研究调查过具有升高的大分子催乳素含量的受试者的心血管代谢危险因素。
我们研究了两组年龄、体重和血压匹配的绝经前妇女：11 名巨泌乳素血症患者和 11 名催乳素水平在参考范围内的妇女。感兴趣的结果包括：葡萄糖稳态标志物、血浆脂质以及尿酸、高敏 C 反应蛋白 (hsCRP)、纤维蛋白原、同型半胱氨酸和 25-羟维生素 D 的血浆水平。
与催乳素水平正常的妇女相比，巨泌乳素血症妇女的 hsCRP 和 2 小时餐后血浆葡萄糖以及胰岛素抵抗评估模型 1 的比值较高，而高密度脂蛋白胆固醇和 25-羟维生素 D 的水平较低。在大-大催乳素水平升高的妇女中，hsCRP 和 25-羟维生素 D 的水平与胰岛素抵抗的程度相关，与高密度脂蛋白胆固醇和 2 小时餐后血浆葡萄糖相似，与巨催乳素含量相关。空腹血糖、总胆固醇、LDL 胆固醇、甘油三酯、尿酸、纤维蛋白原和同型半胱氨酸在两组研究对象之间无差异。
研究结果表明，年轻的巨泌乳素血症妇女似乎具有略高的心血管代谢风险。
