ENT and Head and Neck Research Center, The Five Senses Health Institute, School of Medicine, Hazrate Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, 1445613131, Iran.
Intelligent Systems Research Centre, Ulster University, Derry Campus, Derry~Londonderry, Northern Ireland, UK.
Sci Rep. 2023 Jul 24;13(1):11930. doi: 10.1038/s41598-023-39033-5.
As a common debilitating disorder worldwide, tinnitus requires objective assessment. In the auditory brainstem response (ABR) test, auditory potentials can be evoked by acoustic or optoacoustic (induced by laser light) stimulations. In order to use the ABR test in the objective assessment of tinnitus, in this study, acoustic ABR (aABR) and optoacoustic ABR (oABR) were compared in the control and tinnitus groups to determine the changes caused by sodium salicylate (SS)-induced tinnitus in rat. In both aABR and oABR, wave II was the most prominent waveform, and the amplitude of wave II evoked by oABR was significantly higher than that of aABR. Brainstem transmission time (BTT), which represents the time required for a neural stimulation to progress from the auditory nerve ending to the inferior colliculus, was significantly shorter in oABR. In the tinnitus group, there was a significant increase in the threshold of both ABRs and a significant decrease in the amplitude of wave II only in the oABR. Based on our findings, the ABR test has the potential to be used in the assessment of SS-induced tinnitus, but oABR has the advantages of producing more prominent waveforms and significantly reducing the amplitude of wave II in tinnitus.
作为一种常见的全球致残性疾病，耳鸣需要进行客观评估。在听觉脑干反应（ABR）测试中，可以通过声学或光声（由激光光诱导）刺激来引发听觉电位。为了在耳鸣的客观评估中使用 ABR 测试，在这项研究中，我们比较了对照组和耳鸣组的声学 ABR（aABR）和光声 ABR（oABR），以确定水杨酸钠（SS）诱导的耳鸣在大鼠中引起的变化。在 aABR 和 oABR 中，波 II 都是最突出的波形，而 oABR 诱发的波 II 幅度明显高于 aABR。代表从听神经末梢到下丘脑中枢的神经刺激所需时间的脑干传递时间（BTT）在 oABR 中明显缩短。在耳鸣组中，两种 ABR 的阈值都显著升高，而仅在 oABR 中波 II 的幅度显著降低。根据我们的发现，ABR 测试有可能用于评估 SS 诱导的耳鸣，但 oABR 具有产生更突出的波形和显著降低耳鸣中波 II 幅度的优势。
