Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, Florida.
Division of Cardiovascular Medicine, Department of Medicine, University of Florida, Gainesville, Florida.
JACC Cardiovasc Interv. 2019 Mar 11;12(5):422-430. doi: 10.1016/j.jcin.2018.11.015.
The goal of this study was to investigate the trends, predictors, and outcomes of delayed discharge (>72 h) after transcatheter aortic valve replacement.
Length of stay post-transcatheter aortic valve replacement may have significant clinical and administrative implications.
Data from the Transcatheter Valve Therapy Registry were used to identify patients undergoing nonaborted transfemoral transcatheter aortic valve replacement who survived to discharge, and data linked from the Centers for Medicare & Medicaid Services were used to provide 1-year events. Patients were categorized to early discharge (≤72 h) versus delayed discharge (>72 h). The trends, predictors, and adjusted 1-year outcomes were compared in both groups.
From 2011 to 2015, a total of 13,389 patients (55.1%) were discharged within 72 h, whereas 10,896 patients (44.9%) were discharged beyond 72 h. There was a significant decline in rates of delayed discharge across the study period (62% vs. 34%; p < 0.01). This remained unchanged when stratified by Transcatheter Valve Therapy risk scores. Several factors were identified as independent predictors of early and delayed discharge. After adjustment for in-hospital complications, delayed discharge was an independent predictor of 1-year all-cause mortality (hazard ratio: 1.45; 95% confidence interval: 1.30 to 1.60; p < 0.01).
Rates of delayed discharge have declined from 2011 to 2015. Delayed discharge is associated with a significant increase in mortality even after adjusting for in-hospital complications. Further work is necessary to determine if predictors of early discharge could be used to develop length of stay scores that might be instrumental in administrative, financial, or clinical policy development.
本研究旨在探讨经导管主动脉瓣置换术后(TAVR)延迟出院(>72 小时)的趋势、预测因素和结局。
TAVR 后住院时间可能具有重要的临床和管理意义。
利用经导管瓣膜治疗登记处的数据,确定存活至出院的接受非中止经股 TAVR 的患者,并利用医疗保险和医疗补助服务中心(Centers for Medicare & Medicaid Services)的数据提供 1 年的事件。将患者分为早期出院(≤72 小时)和晚期出院(>72 小时)。比较两组的趋势、预测因素和调整后的 1 年结局。
2011 年至 2015 年,共有 13389 例(55.1%)患者在 72 小时内出院,而 10896 例(44.9%)患者出院时间超过 72 小时。研究期间,延迟出院率显著下降(62% vs. 34%;p<0.01)。按经导管瓣膜治疗风险评分分层后,这一趋势仍然不变。几个因素被确定为早期和晚期出院的独立预测因素。在校正住院期间并发症后,延迟出院是 1 年全因死亡率的独立预测因素(危险比:1.45;95%置信区间:1.30 至 1.60;p<0.01)。
2011 年至 2015 年,延迟出院率呈下降趋势。即使在校正住院期间并发症后,延迟出院与死亡率的显著增加相关。需要进一步的工作来确定早期出院的预测因素是否可以用于制定可能有助于管理、财务或临床政策制定的住院时间评分。