Madsbad S, Gluud C, Bennett P, Krarup T
J Endocrinol Invest. 1986 Feb;9(1):21-5. doi: 10.1007/BF03348056.
Plasma concentrations of testosterone, androstenedione and dihydrotestosterone were measured in 15 Type 1 (insulin-dependent) diabetics with (n = 8) and without (n = 7) B-cell function during 12 h of insulin withdrawal and compared with those of 8 normal subjects. Before insulin withdrawal no significant difference was found in androgen concentrations between the diabetic and the normal subjects. The normal diurnal profiles, with highest androgen concentrations in the morning before insulin withdrawal (08:00) and lowest concentrations at 20:00 h were maintained in the diabetics. However, testosterone and dihydrotestosterone concentrations were lower in the diabetics after 4 h of insulin withdrawal and remained so throughout the study. The concentrations of androstenedione were not significantly different between diabetics and normal subjects except after 4 h of insulin withdrawal. Despite the patients without B-cell function were more metabolically decompensated from after 4 h of insulin withdrawal compared with patients with B-cell function, no significant differences were found in androgen concentrations between the two groups although a tendency to lower concentrations were seen in the group without B-cell function.
在15名1型（胰岛素依赖型）糖尿病患者中，在胰岛素停用12小时期间，对有（n = 8）和无（n = 7）B细胞功能的患者测量了睾酮、雄烯二酮和双氢睾酮的血浆浓度，并与8名正常受试者的浓度进行比较。在胰岛素停用前，糖尿病患者和正常受试者之间的雄激素浓度没有显著差异。糖尿病患者维持了正常的昼夜变化规律，在胰岛素停用前（08:00）早晨雄激素浓度最高，在20:00时浓度最低。然而，胰岛素停用4小时后，糖尿病患者的睾酮和双氢睾酮浓度较低，并且在整个研究过程中一直保持较低水平。除胰岛素停用4小时后外，糖尿病患者和正常受试者之间的雄烯二酮浓度没有显著差异。尽管与有B细胞功能的患者相比，无B细胞功能的患者在胰岛素停用4小时后代谢失代偿更严重，但两组之间的雄激素浓度没有显著差异，尽管在无B细胞功能的组中观察到有浓度降低的趋势。
