抗N-甲基-D-天冬氨酸受体脑炎继发口面部运动障碍导致的严重牙齿脱落
Severe tooth loss secondary to orofacial dyskinesias in anti-NMDA receptor encephalitis.
作者信息
Di Luca Daniel Garbin, Margolesky Jason H
机构信息
Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA.
出版信息
BMJ Case Rep. 2019 Mar 6;12(3):e228380. doi: 10.1136/bcr-2018-228380.
Abstract
A 24-year-old woman with no significant medical or psychiatric history was brought to the emergency department due to altered mental status and bizarre behaviour. Physical examination was remarkable for decreased speech output and orofacial dyskinesia. Upon further evaluation, electroencephalogram showed extreme delta brush waves and cerebrospinal fluid was positive for anti-NMDA receptor antibodies. Despite aggressive treatment with steroids and immunosuppressive therapy, her dyskinesia was severe enough to cause tooth loss, tongue and lip laceration.
摘要
一名24岁女性，无重大内科或精神病史，因精神状态改变和怪异行为被送至急诊科。体格检查发现言语输出减少和口面部运动障碍。进一步评估显示，脑电图呈现极端的δ刷波，脑脊液抗N-甲基-D-天冬氨酸（NMDA）受体抗体检测呈阳性。尽管采用类固醇和免疫抑制疗法积极治疗，但其运动障碍严重到导致牙齿脱落、舌头和嘴唇撕裂伤。
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