Development. 2019 Mar 7;146(5):dev177246. doi: 10.1242/dev.177246.
The control of timing in development is crucial, both within and between tissues. Heterochrony involves shifts in the rate of development of some tissues relative to others, and although the first heterochronic genes were identified in in the early 1980s, their role in inter-tissue developmental coordination is still not completely understood. A new paper in Development tackles this problem with an analysis of the role of , a key heterochronic gene, in worm fertility. We caught up with Sungwook Choi, first author and recently graduated PhD student in Victor Ambros' lab at the University of Massachusetts Medical School in Worcester, to find out more.
发育过程中的时间控制至关重要,无论是在组织内部还是组织之间。时变涉及到一些组织相对于其他组织的发育速度的变化,尽管第一个时变基因是在 20 世纪 80 年代早期被鉴定出来的,但它们在组织间发育协调中的作用仍不完全清楚。《发育》杂志的一篇新论文分析了关键的时变基因在蠕虫生育能力中的作用,解决了这个问题。我们采访了第一作者、维克托·安布罗斯(Victor Ambros)实验室的马萨诸塞大学医学院(University of Massachusetts Medical School)的刚毕业的博士研究生宋武·崔(Sungwook Choi),以了解更多信息。