Priority Research Centre for Healthy Lungs and Centre of Excellence in Severe Asthma, Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia.
Dept of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia.
Eur Respir J. 2019 May 9;53(5). doi: 10.1183/13993003.02058-2018. Print 2019 May.
"Treatable traits" have been proposed as a new paradigm for the management of airway diseases, particularly complex disease, which aims to apply personalised medicine to each individual to improve outcomes. Moving new treatment approaches from concepts to practice is challenging, but necessary. In an effort to accelerate progress in research and practice relating to the treatable traits approach, the Treatable Traits Down Under International Workshop was convened in Melbourne, Australia in May 2018. Here, we report the key concepts and research questions that emerged in discussions during the meeting. We propose a programme of research that involves gaining international consensus on candidate traits, recognising the prevalence of traits, and identifying a potential hierarchy of traits based on their clinical impact and responsiveness to treatment. We also reflect on research methods and designs that can generate new knowledge related to efficacy of the treatable traits approach and consider multidisciplinary models of care that may aid its implementation into practice.
“可治疗性状”已被提议作为气道疾病（尤其是复杂疾病）管理的新模式，其目的是将个体化医疗应用于每个个体，以改善结果。将新的治疗方法从概念转化为实践具有挑战性，但也是必要的。为了加速与可治疗性状方法相关的研究和实践进展，2018 年 5 月在澳大利亚墨尔本召开了“可治疗性状在澳大利亚和新西兰”国际研讨会。在这里，我们报告了会议讨论中出现的关键概念和研究问题。我们提出了一个研究计划，包括就候选性状达成国际共识、认识性状的普遍性，并根据其对治疗的临床影响和反应性确定性状的潜在层次结构。我们还反思了能够产生与可治疗性状方法的疗效相关的新知识的研究方法和设计，并考虑了可能有助于将其付诸实践的多学科护理模式。
