Stony Brook Cancer Center and the Department of Medicine, Health Sciences Center, Stony Brook University, Stony Brook, NY 11794.
Stony Brook Cancer Center and the Department of Medicine, Health Sciences Center, Stony Brook University, Stony Brook, NY 11794; Northport Veterans Affairs Medical Center Northport, NY 11768.
J Lipid Res. 2019 May;60(5):913-918. doi: 10.1194/jlr.S092874. Epub 2019 Mar 7.
Ceramide is a critical bioactive lipid involved in diverse cellular processes. It has been proposed to regulate cellular processes by influencing membrane properties and by directly interacting with effector proteins. Advances over the past decade have improved our understanding of ceramide as a bioactive lipid. Generation and characterization of ceramide-metabolizing enzyme KO mice, development of specific inhibitors and ceramide-specific antibodies, use of advanced microscopy and mass spectrometry, and design of synthetic ceramide derivatives have all provided insight into the signaling mechanisms of ceramide and its implications in disease. As a result, the role of ceramide in biological functions and disease are now better understood, with promise for development of therapeutic strategies to treat ceramide-regulated diseases.
神经酰胺是一种重要的生物活性脂质，参与多种细胞过程。它被认为通过影响膜性质和直接与效应蛋白相互作用来调节细胞过程。过去十年的进展提高了我们对神经酰胺作为生物活性脂质的理解。神经酰胺代谢酶 KO 小鼠的生成和表征、特异性抑制剂和神经酰胺特异性抗体的开发、先进显微镜和质谱的使用以及合成神经酰胺衍生物的设计，都为神经酰胺的信号转导机制及其在疾病中的意义提供了深入的了解。因此，神经酰胺在生物功能和疾病中的作用现在得到了更好的理解，并有望开发出治疗神经酰胺调节疾病的治疗策略。
