Laboratory of Signal Transduction, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
FEBS Lett. 2010 May 3;584(9):1728-40. doi: 10.1016/j.febslet.2010.02.026. Epub 2010 Feb 20.
Recent evidence suggests that ceramide regulates stress signaling via reorganization of the plasma membrane. The focus of this review will be to discuss the mechanism by which acid sphingomyelinase (ASMase)-generated ceramide initiates transmembrane signaling in the plasma membrane exoplasmic leaflet. In particular, we review the unique biophysical properties of ceramide that render it proficient in formation of signaling domains termed ceramide-rich platforms (CRPs), and the role of CRPs in the pathophysiology of various diseases. The biomedical significance of CRPs makes these structures an attractive therapeutic target.
最近的证据表明，神经酰胺通过重塑质膜来调节应激信号。本篇综述的重点将讨论酸性鞘磷脂酶（ASMase）产生的神经酰胺如何在质膜外叶起始跨膜信号转导。特别地，我们将回顾神经酰胺的独特物理化学特性，这些特性使它能够形成信号域，称为神经酰胺富集平台（CRPs），以及 CRPs 在各种疾病的病理生理学中的作用。CRPs 的生物医学意义使这些结构成为有吸引力的治疗靶点。
