Laboratory of Epigenetics, Cancer Research Institute, Seoul National University College of Medicine, Seoul, 03080, Korea.
Department of Pathology, Seoul National University College of Medicine, Seoul, 03080, Korea.
Sci Rep. 2019 Mar 7;9(1):3808. doi: 10.1038/s41598-019-40527-4.
CD103 is a transmembrane heterodimer complex that mediates cell adhesion, migration, and lymphocyte homing of cell through interaction with E-cadherin. Recently, CD103+ immune cells in human carcinoma has been investigated as a prognostic factor, however, the correlation between CD103+ immune cells and survival are still elusive. Therefore, a meta-analysis was performed to determine the prognostic value of CD103+ immune cells in solid tumor. Studies relevant to the subject was searched from PubMed, Embase, and Web of Science. Ten studies including 2,824 patients were eligible for the analysis. Tumors positive for CD103+ immune cells were associated with favorable overall survival, disease-free survival, and disease-specific survival. Subgroup analysis revealed that assessing CD103+ immune cells in epithelial and total (both epithelial and stromal) areas or using whole slide section were associated with good prognosis. Furthermore, stromal CD103+ immune cells or CD103+ immune cells evaluated by tissue microarrays were not always significantly prognostic. In conclusion, these results show that CD103+ immune cells are associated with prognosis in solid tumor. However, the region of assessment and selection of material for the evaluation could affect the value of CD103 as a prognostic biomarker.
CD103 是一种跨膜异二聚体复合物，通过与 E-钙黏蛋白相互作用介导细胞黏附、迁移和淋巴细胞归巢。最近，人类癌组织中的 CD103+免疫细胞已被研究作为一种预后因素，然而，CD103+免疫细胞与生存之间的相关性仍不清楚。因此，进行了荟萃分析以确定 CD103+免疫细胞在实体瘤中的预后价值。从 PubMed、Embase 和 Web of Science 中搜索与主题相关的研究。共有 10 项研究，包括 2824 名患者符合分析条件。CD103+免疫细胞阳性的肿瘤与总生存、无病生存和疾病特异性生存相关。亚组分析显示，评估上皮和总（上皮和基质）区域的 CD103+免疫细胞或使用全切片进行评估与良好的预后相关。此外，基质 CD103+免疫细胞或通过组织微阵列评估的 CD103+免疫细胞并不总是具有显著的预后价值。总之，这些结果表明 CD103+免疫细胞与实体瘤的预后相关。然而，评估区域和评估材料的选择可能会影响 CD103 作为预后生物标志物的价值。
