Birkhahn R H, Askari A, Thomford N R
J Nutr. 1986 May;116(5):851-64. doi: 10.1093/jn/116.5.851.
Total parenteral nutrition (TPN) by means of monoacetoacetin (glycerol monoacetoacetate) was compared with TPN by using glucose-glycerol. Growth and urinary nitrogen, copper and zinc over 7 d and leucine dynamics on the last day were studied. Complete intravenous diets were administered to five groups of rats which were differentiated by receiving 45 kcal/d (group A) or 65 kcal/d (group C) from a 50% glucose-50% glycerol mixture, 45 kcal/d (group B) or 65 kcal/d (group D) from a 67% monoacetoacetin-33% glucose mixture, or 45 kcal/d (group E) from 100% monoacetoacetin. Leucine kinetics were determined by continuous infusion. Animals from groups A and C were hyperglycemic and normoketonemic, groups B and D were normoglycemic and hyperketonemic, and group E tended to be normoglycemic and hyperketonemic. Group B rats gained weight and retained the most nitrogen while groups A and E lost weight and groups C and D maintained their weight. Nitrogen losses correlated with weight changes. Urinary copper and zinc were not increased by giving ketone bodies. Leucine kinetics were found to be low for group C compared to its energy-matched group, and leucine metabolism was not correlated with nitrogen output and growth. The data suggest that a monoacetoacetin-glucose mixture is preferable as a nonprotein energy source for TPN when compared to either substance alone.
通过单乙酰乙酸甘油酯（甘油单乙酰乙酸酯）进行的全胃肠外营养（TPN）与使用葡萄糖 - 甘油进行的TPN相比较。研究了7天内的生长情况、尿氮、铜和锌水平以及最后一天的亮氨酸动力学。给五组大鼠喂食完全静脉内饮食，这些组通过接受来自50%葡萄糖 - 50%甘油混合物的45千卡/天（A组）或65千卡/天（C组）、来自67%单乙酰乙酸甘油酯 - 33%葡萄糖混合物的45千卡/天（B组）或65千卡/天（D组），或来自100%单乙酰乙酸甘油酯的45千卡/天（E组）来区分。通过持续输注测定亮氨酸动力学。A组和C组动物血糖高且酮体正常，B组和D组动物血糖正常且酮体高，E组动物倾向于血糖正常且酮体高。B组大鼠体重增加且保留的氮最多，而A组和E组体重减轻，C组和D组体重维持不变。氮损失与体重变化相关。给予酮体并未增加尿铜和锌。发现C组的亮氨酸动力学与其能量匹配组相比很低，并且亮氨酸代谢与氮输出和生长无关。数据表明，与单独使用任何一种物质相比，单乙酰乙酸甘油酯 - 葡萄糖混合物作为TPN的非蛋白质能量来源更可取。
