Birkhahn R H, Askari A, Thomford N R
Department of Surgery, Medical College of Ohio, Toledo 43699.
J Surg Res. 1988 Feb;44(2):160-5. doi: 10.1016/0022-4804(88)90044-3.
Intravenous glucose and ketone body feeding were compared for their potential in altering urinary nitrogen losses by the traumatized rat. Eighteen male rats were traumatized by bilateral femoral fracture. The rats were fed totally by vein for 3 days prior and 3 days after injury and the infusion rate was held constant over the 6 days of infusion. Group GT rats were fed glucose as the source of nonprotein energy while group MT rats were fed a mixture of 72% monoacetoacetin (the monoglyceride of acetoacetate)-28% glucose for the nonprotein energy. Total urinary nitrogen excretion on a 24-hr basis was measured for each of the 6 days of intravenous feeding. On the third day post-trauma, each rat was evaluated for leucine kinetics using a continuous infusion of L-[1-14C]leucine and measurement of breath and plasma specific activities. Rats from group MT were hyperketonemic and normoglycemic and rats from group GT were normoketonemic and hyperglycemic. Urinary nitrogen losses, leucine oxidation, and leucine turnover were similar for the two groups. We conclude that ketone bodies are as good an intravenous source of energy as is glucose, and the ketone bodies do not cause hyperglycemia.
比较了静脉输注葡萄糖和酮体对创伤大鼠尿氮损失的影响。18只雄性大鼠通过双侧股骨骨折造成创伤。在受伤前3天和受伤后3天通过静脉对大鼠进行全肠外营养，在6天的输注过程中输注速率保持恒定。GT组大鼠输注葡萄糖作为非蛋白能量来源，而MT组大鼠输注72%单乙酰乙酸甘油酯（乙酰乙酸单甘油酯）-28%葡萄糖的混合物作为非蛋白能量来源。在静脉营养的6天中，每天测量24小时尿氮总排泄量。创伤后第三天，通过持续输注L-[1-14C]亮氨酸并测量呼出气体和血浆比活度，对每只大鼠进行亮氨酸动力学评估。MT组大鼠血酮水平升高但血糖正常，GT组大鼠血酮水平正常但血糖升高。两组大鼠的尿氮损失、亮氨酸氧化和亮氨酸周转率相似。我们得出结论，酮体作为静脉能量来源与葡萄糖一样好，并且酮体不会导致高血糖。
