Kurashima C, Hirokawa K
J Oral Pathol. 1986 Mar;15(3):172-8. doi: 10.1111/j.1600-0714.1986.tb00601.x.
Histopathological studies were made on the submandibular glands, obtained from 207 autopsy cases of patients, ranging in age from 40-98 years who had not had collagen diseases. Focal lymphocytic infiltration of the submandibular glands was more frequently seen in the cases of patients over 70 years (80.3%) than in those of under 70 years (53.8%). Generally, the incidence of focal lymphocytic infiltration showed a trend to gradual increase with age. Immunohistochemically, a predominance of T cells (60-80%) was found in submandibular lesions with the majority (60-70%) belonging to the Leu 3a+ subset (Helper/Inducer) and with less than 20% belonging to the Leu 2a+ subset (Cytotoxic/Suppressor). The percentage of Leu 2a+ subset was found to increase in the lesion of the periacinar area, and the acinar parenchyma appeared gradually to be damaged by the infiltrating lymphocytes. The findings in the present study suggest that focal lymphocytic infiltration in submandibular glands is a focal sign of immunological disorder, based on the autoimmunity associated with aging.
对207例年龄在40 - 98岁之间且无胶原病的患者尸检病例的下颌下腺进行了组织病理学研究。70岁以上患者（80.3%）的下颌下腺局灶性淋巴细胞浸润比70岁以下患者（53.8%）更常见。一般来说，局灶性淋巴细胞浸润的发生率呈随年龄逐渐增加的趋势。免疫组织化学研究发现，下颌下病变中T细胞占优势（60 - 80%），其中大多数（60 - 70%）属于Leu 3a +亚群（辅助/诱导型），而属于Leu 2a +亚群（细胞毒性/抑制型）的不到20%。发现Leu 2a +亚群的百分比在腺泡周围区域的病变中增加，腺泡实质逐渐被浸润的淋巴细胞破坏。本研究结果表明，基于与衰老相关的自身免疫，下颌下腺的局灶性淋巴细胞浸润是免疫紊乱的局灶性征象。
