Kurashima C, Hirokawa K
Surv Synth Pathol Res. 1985;4(5-6):457-66. doi: 10.1159/000156996.
Histopathological studies were made on the thyroid glands obtained from 169 autopsy cases of patients, ranging in age from 63 to 97 years, who had not had collagen diseases. Focal lymphocytic infiltration was found in 29 (17.2%) of 169 thyroid glands. Although the relationship between the incidence and age was unclear among elderly people, there was a tendency of a prevalence in females with respect to severity of focal lymphocytic infiltration. Immunohistochemically, a predominance of T cells (80-90%) was found in the thyroid lesions. The infiltrating T cells were composed of chiefly OKT 4+ or Leu 3a+ subset (60-80%) and lesser number of OKT 8+ or Leu 2a+ subset (20-40%). An increase in the percentage of OKT 8+ or Leu 2a+ cells, however, was observed in the tiny lesions infiltrating the interfollicular connective tissues. In aged patients over 63 years old, the average weight of thyroid glands without lymphocytic infiltration, obtained from female patients, was approximately 11 g, and the average weight of those with focal lymphocytic infiltration was approximately 17 g, whereas there was no significant difference in the weight of thyroid glands obtained from male patients with and without focal lymphocytic infiltration (14 g). The findings in the present study suggest that focal lymphocytic infiltration in thyroid glands is a focal sign of an immunological disorder which is based on autoimmunity associated with aging.
对169例年龄在63岁至97岁之间、无胶原病的患者尸检获得的甲状腺进行了组织病理学研究。在169个甲状腺中，29个（17.2%）发现有局灶性淋巴细胞浸润。尽管在老年人中发病率与年龄的关系尚不清楚，但就局灶性淋巴细胞浸润的严重程度而言，女性有患病率较高的趋势。免疫组织化学检查发现，甲状腺病变中T细胞占优势（80%-90%）。浸润的T细胞主要由OKT 4+或Leu 3a+亚群（60%-80%）组成，OKT 8+或Leu 2a+亚群数量较少（20%-40%）。然而，在浸润滤泡间结缔组织的微小病变中，观察到OKT 8+或Leu 2a+细胞的百分比增加。在63岁以上的老年患者中，女性患者无淋巴细胞浸润的甲状腺平均重量约为11g，有局灶性淋巴细胞浸润的甲状腺平均重量约为17g，而男性患者有和无局灶性淋巴细胞浸润的甲状腺重量无显著差异（14g）。本研究结果表明，甲状腺的局灶性淋巴细胞浸润是一种基于与衰老相关的自身免疫的免疫紊乱的局灶性表现。
