Department of Radiology, Kaiser Permanente Oakland Medical Center, Oakland, California.
Department of Otolaryngology - Head and Neck Surgery, University of California San Francisco, San Francisco, California.
Head Neck. 2019 May;41(5):1161-1164. doi: 10.1002/hed.25365. Epub 2019 Mar 7.
Differentiating esthesioneuroblastoma (ENB) from other sinonasal tumors is difficult by MRI. We tested whether diffusion weighted imaging (DWI) could distinguish ENB from other sinonasal tumors.
Hundred forty-six patients underwent sinonasal MRI, 75 with technically successful DWI. Pathology: 18 ENB (24%), 34 (45%) other malignant tumors, and 23 (31%) benign lesions. Apparent diffusion coefficients (ADCs) were calculated.
Average ADC and normalized ADC of ENB (1.22 × 10 ± 0.28 mm /s and 1.55 ± 0.36, respectively) were higher than other malignancies (0.98 × 10 ± 0.18 mm /s and 1.31 ± 0.29, P = .002 and P = .034) and lower than benign disease (1.92 × 10 ± 0.33 mm /s and 2.44 ± 0.50, P < .0001). ADC differentiated ENB from benign disease with 91% sensitivity and 83% specificity. An ADC cutoff of 1.1 × 10 mm /s differentiated other malignancies from ENB with 72% sensitivity and 85% specificity.
DWI is useful in distinguishing ENB from other sinonasal disease.
磁共振成像（MRI）难以区分嗅神经母细胞瘤（ENB）和其他鼻腔鼻窦肿瘤。我们检测了弥散加权成像（DWI）是否能区分 ENB 和其他鼻腔鼻窦肿瘤。
146 例患者接受了鼻腔鼻窦 MRI 检查，其中 75 例技术上成功进行了 DWI。病理结果：18 例 ENB（24%）、34 例（45%）其他恶性肿瘤和 23 例（31%）良性病变。计算表观弥散系数（ADC）。
ENB 的平均 ADC 和标准化 ADC（分别为 1.22×10±0.28mm/s 和 1.55±0.36）高于其他恶性肿瘤（分别为 0.98×10±0.18mm/s 和 1.31±0.29，P=0.002 和 P=0.034），低于良性病变（分别为 1.92×10±0.33mm/s 和 2.44±0.50，P<0.0001）。ADC 以 91%的灵敏度和 83%的特异性区分 ENB 与良性疾病。ADC 截断值为 1.1×10mm/s 时，以 72%的灵敏度和 85%的特异性区分其他恶性肿瘤与 ENB。
DWI 有助于区分 ENB 和其他鼻腔鼻窦疾病。
