Ito Y, Katoh N, Takeda A, Kanematsu M, Ban Y, Nishiura T, Sakai S, Fujihiro S, Doi T, Tei K
Jpn J Antibiot. 1986 Jan;39(1):9-16.
Twenty-one nongonococcal urethritis patients by Chlamydia trachomatis infection were treated with doxycycline (DOXY, Vibramycin) 200 mg/day orally for 2 weeks. The age of these patients were ranged from 17 to 52. C. trachomatis was eradicated 8(89%) of 9 cases on 3rd day and never reisolated on 7th day after treatment. Ten (83%) of 12 patients on 7th day and any patients on 14th day were not suffered from symptoms after treatment. Urethral discharge was not seen macroscopically, 11 (92%) of 12 patients on 7th day and any patients on 14th day. According to the criteria for urethritis requiring at least 4 WBC per high power field in urethral smear and/or first voided urine, the overall clinical efficacy rate was 44% (4/9) on 3rd day, 83% (10/12) on 7th day and 100% (9/9) on 14th day. No side effects were recognized in any cases. In conclusion, DOXY was thought to be useful and safe drug in the treatment of nongonococcal urethritis by C. trachomatis.
21例沙眼衣原体感染所致非淋菌性尿道炎患者，口服强力霉素（DOXY，威霸霉素）200mg/天，疗程2周。这些患者年龄在17至52岁之间。9例患者中8例（89%）在治疗第3天沙眼衣原体被清除，治疗后第7天未再分离到该病原体。12例患者中有10例（83%）在治疗第7天症状消失，治疗第14天所有患者症状均消失。肉眼未见尿道分泌物，12例患者中有11例（92%）在治疗第7天未见尿道分泌物，治疗第14天所有患者均未见。根据尿道涂片和/或首次晨尿每高倍视野至少4个白细胞的尿道炎诊断标准，总体临床有效率在治疗第3天为44%（4/9），第7天为83%（10/12），第14天为100%（9/9）。所有病例均未发现副作用。总之，强力霉素被认为是治疗沙眼衣原体所致非淋菌性尿道炎的有效且安全的药物。
