健康儿童和青少年瘦素/脂联素比值的参考值。
Reference values for leptin/adiponectin ratio in healthy children and adolescents.
机构信息
Department of Neonatology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark; The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark.
The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark; Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
出版信息
Clin Chim Acta. 2019 Jun;493:123-128. doi: 10.1016/j.cca.2019.03.004. Epub 2019 Mar 6.
BACKGROUND
Leptin and adiponectin are two key adipocyte secreted hormones and both are involved in several essential physiological mechanisms. Due to their central role in energy homeostasis their ratio, the leptin/adiponectin ratio, is believed to be a marker of metabolic derangement. Pediatric reference values are needed for the risk stratification of individual-measured ratios.
METHODS
Blood samples were drawn from healthy, Danish schoolchildren following an overnight fast. A ratio was calculated from serum leptin and adiponectin quantifications done using commercially available ELISA Kits.
RESULTS
Nine hundred eighty-three participants (583 girls) aged 6-18 years were included. Smoothed percentile curves and age-group specific percentiles were calculated. A correlation with age was demonstrated, with a gradual increase with age in girls and a negative parabolic relation, with a peak in age group 10-14, in boys. The leptin/adiponectin ratio was positively correlated to the body mass index standard deviation score for both girls and boys (p < .001).
CONCLUSION
The leptin/adiponectin ratio is correlated to age and differs between the sexes in healthy children and adolescents.
背景
瘦素和脂联素是两种关键的脂肪细胞分泌激素，它们都参与了几个重要的生理机制。由于它们在能量平衡中的核心作用，它们的比值（瘦素/脂联素比值）被认为是代谢紊乱的一个标志物。需要有儿科参考值来对个体测量比值进行风险分层。
方法
对丹麦健康的学童进行了一次过夜禁食后的血液采样。使用市售的 ELISA 试剂盒对血清瘦素和脂联素进行定量，计算出比值。
结果
共纳入 983 名参与者（583 名女孩），年龄在 6-18 岁之间。计算了平滑百分位数曲线和年龄组特异性百分位数。结果显示，女孩的比值随年龄逐渐增加，男孩的比值呈负抛物线关系，在 10-14 岁年龄组达到峰值。瘦素/脂联素比值与女孩和男孩的体重指数标准差评分呈正相关（p <.001）。
结论
在健康的儿童和青少年中，瘦素/脂联素比值与年龄相关，并且在性别之间存在差异。
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