Nishimura Rimei, Sano Hironari, Matsudaira Toru, Morimoto Aya, Miyashita Yumi, Shirasawa Takako, Kokaze Akatsuki, Tajima Naoko
Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Cardiovasc Diabetol. 2009 Jun 3;8:30. doi: 10.1186/1475-2840-8-30.
The study examined changes in and relationship between body mass index (BMI), leptin and adiponectin levels over a 3-year period in a pediatric population-based cohort.
A 3-year prospective cohort study of 268 boys and 251 girls aged 9-10 in Ina, Saitama, Japan.
Median body mass index (BMI) significantly increased from baseline (age 9-10) to follow up (age 12-13) in boys from 17.1 to 18.3 kg/m2 (P < 0.001) and in girls from 16.5 to 18.5 kg/m2 (P < 0.001), respectively. Adiponectin values significantly decreased from baseline to follow up in boys (13.5 to 8.9 microg/ml, respectively) (P < 0.001) and in girls (12.4 to 9.5 microg/ml, respectively) (P < 0.001). Leptin values at follow up significantly decreased from baseline in boys (4.9 to 2.3 ng/dl, respectively) (P < 0.001) and also in girls (5.3 to 5.1 ng/dl, respectively) (P = 0.049). A relatively strong correlation was seen in BMI (Spearman's correlation coefficient, r = 0.864, P < 0.001 in boys; r = 0.873, P < 0.001 in girls), adiponectin (r = 0.705, P < 0.001 in boys; r = 0.695, P < 0.001 in girls), and leptin (r = 0.449, P < 0.001 in boys; r = 0.610, P < 0.001 in girls) before and after the three-year period. The ratio of follow up to baseline BMI was negatively correlated with that for adiponectin (r = -0.224, P < 0.001 in boys; r = -0.165, P = 0.001 in girls) and positively correlated with that for leptin (r = 0.518, P < 0.001 in boys; r = 0.609, P < 0.001 in girls).
This study demonstrated that baseline adiponectin, leptin and BMI values measured at ages 9-10 correlated with those measured three years later. However, adiponectin values decreased and leptin values increased in those subjects whose BMI increased during over this period.
本研究调查了一个基于人群的儿科队列中，三年间体重指数（BMI）、瘦素和脂联素水平的变化及其相互关系。
对日本埼玉县伊奈市268名9 - 10岁男孩和251名9 - 10岁女孩进行为期三年的前瞻性队列研究。
男孩的体重指数中位数从基线（9 - 10岁）到随访（12 - 13岁）显著增加，从17.1增至18.3kg/m²（P < 0.001），女孩从16.5增至18.5kg/m²（P < 0.001）。脂联素值在男孩中从基线到随访显著降低（分别为13.5至8.9μg/ml）（P < 0.001），在女孩中也显著降低（分别为12.4至9.5μg/ml）（P < 0.001）。随访时男孩的瘦素值从基线显著降低（分别为4.9至2.3ng/dl）（P < 0.001），女孩也显著降低（分别为5.3至5.1ng/dl）（P = 0.049）。在三年前后，BMI（男孩的斯皮尔曼相关系数r = 0.864，P < 0.001；女孩的r = 0.873，P < 0.001）、脂联素（男孩的r = 0.705，P < 0.001；女孩的r = 0.695，P < 0.001）和瘦素（男孩的r = 0.449，P < 0.001；女孩的r = 0.610，P < 0.001）之间存在较强的相关性。随访与基线BMI的比值与脂联素的比值呈负相关（男孩的r = -0.224，P < 0.001；女孩的r = -0.165，P = 0.001），与瘦素的比值呈正相关（男孩的r = 0.518，P < 0.001；女孩的r = 0.609，P < 0.001）。
本研究表明，9 - 10岁时测量的基线脂联素、瘦素和BMI值与三年后测量的值相关。然而，在此期间BMI增加的受试者中，脂联素值降低，瘦素值增加。
