Skarpaas Tara L, Jarosiewicz Beata, Morrell Martha J
NeuroPace, Inc., Mountain View, CA, United States.
NeuroPace, Inc., Mountain View, CA, United States.
Epilepsy Res. 2019 Jul;153:68-70. doi: 10.1016/j.eplepsyres.2019.02.003. Epub 2019 Feb 20.
Controlled clinical trials in adults with medically intractable focal seizures treated with the RNS System demonstrate that closed-loop responsive neurostimulation to the seizure focus reduces the frequency of disabling seizures, is well tolerated, and is acceptably safe. Seizure reductions begin with initiation of treatment and continue over time, reaching median reductions of 75% after 9 years of treatment. Treatment with responsive cortical stimulation is also associated with improvement in quality of life and cognitive function related to the functional area being treated. In addition, the RNS System's chronic ambulatory electrocorticographic monitoring provides unprecedented insight into each patient's disease management, and into the study of epilepsy itself, in ways that may enhance the treatment of epilepsy in the future.
针对使用RNS系统治疗的药物难治性局灶性癫痫成人患者进行的对照临床试验表明，对癫痫病灶进行闭环响应性神经刺激可降低致残性癫痫发作的频率，耐受性良好且安全性可接受。癫痫发作减少从治疗开始时就出现，并随时间持续，治疗9年后中位数减少75%。响应性皮质刺激治疗还与生活质量改善以及与所治疗功能区相关的认知功能改善有关。此外，RNS系统的慢性动态皮质脑电图监测以前所未有的方式为每位患者的疾病管理以及癫痫本身的研究提供了见解，这可能会在未来加强癫痫的治疗。
