联合抗氧化剂和糖皮质激素治疗以更安全地治疗早产。
Combined Antioxidant and Glucocorticoid Therapy for Safer Treatment of Preterm Birth.
机构信息
Department of Physiology Development & Neuroscience, University of Cambridge, Cambridge, UK; Cambridge Cardiovascular Strategic Research Initiative, University of Cambridge, Cambridge, UK; Cambridge Strategic Research Initiative on Reproduction, University of Cambridge, Cambridge, UK.
Department of Physiology Development & Neuroscience, University of Cambridge, Cambridge, UK; Cambridge Cardiovascular Strategic Research Initiative, University of Cambridge, Cambridge, UK; Cambridge Strategic Research Initiative on Reproduction, University of Cambridge, Cambridge, UK.
出版信息
Trends Endocrinol Metab. 2019 Apr;30(4):258-269. doi: 10.1016/j.tem.2019.02.003. Epub 2019 Mar 5.
Ante- and postnatal glucocorticoid therapy reduces morbidity and mortality in the preterm infant, and it is therefore one of the best examples of the successful translation of basic experimental science into human clinical practice. However, accruing evidence derived from human clinical studies and from experimental studies in animal models raise serious concerns about potential long-term adverse effects of treatment on growth and neurological and cardiovascular function in the offspring. This review explores whether combined antioxidant and glucocorticoid therapy may be safer than glucocorticoid therapy alone for the treatment of preterm birth.
产前和产后糖皮质激素治疗可降低早产儿的发病率和死亡率，因此这是将基础实验科学成功转化为人类临床实践的最佳范例之一。然而，来自人类临床研究和动物模型实验研究的累积证据对治疗对后代生长以及神经和心血管功能的潜在长期不良影响提出了严重关切。本综述探讨了联合抗氧化剂和糖皮质激素治疗是否比单独糖皮质激素治疗更安全，用于治疗早产。
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