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腔内治疗股腘动脉病变后单纯球囊扩张支架置入与全覆膜支架置入的比较。

Spot stenting versus full coverage stenting after endovascular therapy for femoropopliteal artery lesions.

机构信息

Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.

Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan.

出版信息

J Vasc Surg. 2019 Oct;70(4):1166-1176. doi: 10.1016/j.jvs.2018.12.044. Epub 2019 Mar 6.

DOI:10.1016/j.jvs.2018.12.044
PMID:30850285
Abstract

OBJECTIVE

Although spot stenting (SS) for femoropopliteal (FP) lesions has been preferred compared with full coverage stenting (FCS), which stenting strategy results in better outcomes has remained unclear in the real-world clinical setting. Therefore, we compared the clinical outcomes of SS and FCS for FP lesions using a propensity-matched analysis.

METHODS

The present multicenter, retrospective study examined data from a clinical database of 1554 consecutive patients who had undergone FP endovascular therapy for symptomatic peripheral artery disease from January 2010 to December 2016. Of these patients, 1151 had undergone FP stenting. The outcome measures were primary patency and primary assisted patency obtained using propensity score matching. Interaction analysis was also performed to explore the effects of the baseline characteristics on the association between SS and primary patency.

RESULTS

After propensity score matching, SS for FP lesions demonstrated a significantly lower primary patency rate compared with FCS at 3 years (29% vs 53%; P = .011). Additionally, primary assisted patency at 3 years was significantly lower in the group with SS than in the FCS group (53% vs 72%; P = .014). Interaction analysis showed that chronic total occlusion lesions, lesion location A (proximal superficial femoral artery portion), and lesion length ≥138 mm were associated with the noninferiority of SS compared with FCS for primary patency.

CONCLUSIONS

The propensity-matched analysis demonstrated that primary patency and primary assisted patency at 3 years were significantly lower with SS compared with FCS for FP lesions in real-world clinical settings. The interaction analysis suggested that SS might be suited to more complex FP lesions (ie, chronic total occlusion lesions, proximal superficial femoral artery lesion, lesion length ≥138 mm).

摘要

目的

与全覆膜支架置入术(FCS)相比,点状支架置入术(SS)治疗股腘动脉(FP)病变更受青睐,但在真实临床环境中,哪种支架置入策略的效果更好仍不清楚。因此,我们采用倾向评分匹配分析比较了 SS 和 FCS 治疗 FP 病变的临床结果。

方法

本多中心回顾性研究纳入了 2010 年 1 月至 2016 年 12 月期间因症状性外周动脉疾病行 FP 腔内治疗的 1554 例连续患者的临床数据库资料。其中 1151 例行 FP 支架置入术。使用倾向评分匹配评估主要通畅率和主要辅助通畅率作为观察指标。还进行了交互分析,以探讨基线特征对 SS 与主要通畅率之间关系的影响。

结果

经倾向评分匹配后,与 FCS 相比,SS 治疗 FP 病变的 3 年主要通畅率显著较低(29% vs 53%;P =.011)。此外,SS 组的 3 年主要辅助通畅率显著低于 FCS 组(53% vs 72%;P =.014)。交互分析显示,慢性完全闭塞病变、病变位置 A(股浅动脉近端)和病变长度≥138mm 与 SS 治疗 FP 病变的非劣效性相关。

结论

倾向评分匹配分析表明,在真实临床环境中,与 FCS 相比,SS 治疗 FP 病变的 3 年主要通畅率和主要辅助通畅率显著较低。交互分析提示,SS 可能更适合复杂的 FP 病变(即慢性完全闭塞病变、股浅动脉近端病变、病变长度≥138mm)。

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