Department of Microbiology, Biochemistry and Immunology; Cancer Health Equity Institute, Morehouse School of Medicine, Atlanta, GA, 30310, USA.
Division of Preventive Medicine, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Sci Rep. 2019 Mar 8;9(1):4014. doi: 10.1038/s41598-019-40514-9.
Despite recent advances, breast cancer (BrCa) still affects many women and the impact is disproportional in African Americans (AA) compared to European Americans (EA). Addressing socioeconomic and behavioral status has not been enough to reduce disparity, suggesting contribution of biological differences in BrCa disparity. Our laboratory was first to show involvement of CC chemokines in BrCa. In this study, using ONCOMINE, TCGA, bc-GenExMiner and KMplotter, we examined the association of CC chemokines in BrCa outcomes and disparity. We show over-expression of CCL5, -7, -11, -17, -20, -22 and -25 in BrCa tissues. High mRNA levels of CCL7, -8, -17, -20 and -25 predicted a decrease in overall survival (OS). CCL7 and CCL8 were associated with decreased relapse-free survival. Expression of CCL17 and CCL25 was associated with decreased OS in AA. In EA, CCL8 was associated with decreased OS. Expression of CCL5, -7, -8, -17, -20 and -25 was highest in TNBC. Expression of CCL11 and CCL22 was associated with HER2. CCL7, -8, -17, -20 and -25 were elevated in AAs. In conclusion, our analysis suggests significant association of CC-chemokines in BrCa progression, OS and disparate disease outcome in AA compared to EA patients.
尽管最近取得了进展，但乳腺癌（BrCa）仍然影响着许多女性，非裔美国人（AA）的影响不成比例，与欧洲裔美国人（EA）相比。解决社会经济和行为状况还不足以缩小差距，这表明 BrCa 差异中存在生物学差异的贡献。我们的实验室是第一个证明 CC 趋化因子参与 BrCa 的实验室。在这项研究中，我们使用 ONCOMINE、TCGA、bc-GenExMiner 和 KMplotter，研究了 CC 趋化因子在 BrCa 结果和差异中的关联。我们显示 CCL5、-7、-11、-17、-20、-22 和 -25 在 BrCa 组织中过度表达。CCL7、-8、-17、-20 和 -25 的高 mRNA 水平预测总生存期（OS）下降。CCL7 和 CCL8 与无复发生存率降低相关。CCL17 和 CCL25 的表达与 AA 中 OS 降低相关。在 EA 中，CCL8 与 OS 降低相关。CCL5、-7、-8、-17、-20 和 -25 的表达在 TNBC 中最高。CCL11 和 CCL22 的表达与 HER2 相关。CCL7、-8、-17、-20 和 -25 在 AAs 中升高。总之，我们的分析表明，CC 趋化因子在 BrCa 进展、OS 和 AA 患者与 EA 患者相比差异明显的疾病结局中存在显著关联。
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