Castillo Andres, Osorio Julio Cesar, Fernández Adrián, Méndez Fabián, Alarcón Liliana, Arturo Gabriela, Herrero Rolando, Bravo Luis Eduardo
Department of Biology, School of Natural and Exact Sciences, Universidad del Valle, Colombia.
Doctoral Program in Biomedical Sciences, School of Basic Sciences, Universidad del Valle, Cali, Colombia.
Papillomavirus Res. 2019 Jun;7:112-117. doi: 10.1016/j.pvr.2019.03.001. Epub 2019 Mar 7.
In recent years, an association between HPV-16 and oropharyngeal cancers has been reported. Therefore, it is necessary to evaluate whether vaccination decreases the exposure of HPV-16 in the oral cavity.
To evaluate the effect of vaccination on oral HPV-16 infection in high school students in the city of Cali, Colombia.
In this cross-sectional study, HPV-16 DNA was detected in samples from the oral cavity and throat of 1,784 high school students of both genders, aged 14-17 years old, in 21 schools in the city of Cali, Colombia. The number in vaccinated girls were 944 vs., 95 unvaccinated girls and 745 unvaccinated boys.
The HPV exposure percentages were: 0.7% in vaccinated girls, 3.2% in unvaccinated girls and 2.3% in unvaccinated boys. The odds ratio (OR) of detection of HPV-16 in vaccinated versus unvaccinated students was 0.28 (95% CI: 0.07-0.88), representing a 72% reduction in HPV-16 detection in students immunized with two doses. The odds of detection of HPV-16 in unvaccinated male students were 3.6 times those of vaccinated girls (OR = 3.6, 95% CI: 1.21-12.81) and increased to almost eight-fold in boys who had initiated sexual activity (OR = 7.74, 95% CI: 1.53-75.09).
HPV vaccination was associated with the reduction of HPV-16 exposure percentages in the oral and oropharyngeal cavity.
近年来，有报道称人乳头瘤病毒16型（HPV - 16）与口咽癌之间存在关联。因此，有必要评估接种疫苗是否能降低口腔中HPV - 16的暴露。
评估接种疫苗对哥伦比亚卡利市高中生口腔HPV - 16感染的影响。
在这项横断面研究中，对哥伦比亚卡利市21所学校的1784名年龄在14 - 17岁的男女高中生的口腔和咽喉样本进行HPV - 16 DNA检测。接种疫苗的女孩有944名，未接种疫苗的女孩有95名，未接种疫苗的男孩有745名。
HPV暴露百分比分别为：接种疫苗的女孩为0.7%，未接种疫苗的女孩为3.2%，未接种疫苗的男孩为2.3%。接种疫苗与未接种疫苗的学生中检测到HPV - 16的比值比（OR）为0.28（95%置信区间：0.07 - 0.88），这表明接种两剂疫苗的学生中HPV - 16检测率降低了72%。未接种疫苗的男学生检测到HPV - 16的几率是接种疫苗女孩的3.6倍（OR = 3.6，95%置信区间：1.21 - 12.81），而在开始有性行为的男孩中这一几率增加到近8倍（OR = 7.74，95%置信区间：1.53 - 75.09）。
HPV疫苗接种与口腔和口咽腔中HPV - 16暴露百分比的降低有关。
